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Title: Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action

Journal Article · · Nature Communications
DOI:https://doi.org/10.1038/ncomms6935· OSTI ID:1168512
 [1];  [1];  [1];  [2];  [1];  [3];  [3];  [2];  [1]
  1. Georgia State Univ., Atlanta, GA (United States)
  2. Brookhaven National Lab. (BNL), Upton, NY (United States)
  3. Kansai Univ., Osaka (Japan)
+ Show Author Affiliations

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States); Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
Grant/Contract Number:
SC00112704; AC02-98CH10886; W-31-109-ENG-38; AC02-06CH11357
OSTI ID:
1168512
Alternate ID(s):
OSTI ID: 1201330
Report Number(s):
BNL-107771-2015-JA; ncomms6935
Journal Information:
Nature Communications, Vol. 6; ISSN 2041-1723
Publisher:
Nature Publishing GroupCopyright Statement
Country of Publication:
United States
Language:
ENGLISH
Citation Metrics:
Cited by: 16 works
Citation information provided by
Web of Science

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Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease journal November 2002
Involvement of Glutamate 268 in the Active Site of Human Liver Mitochondrial (Class 2) Aldehyde Dehydrogenase As Probed by Site-Directed Mutagenesis journal January 1995
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Endogenous kynurenines as targets for drug discovery and development journal August 2002
The kynurenine pathway of tryptophan degradation as a drug target journal February 2004
A novel degradative pathway of 2-nitrobenzoate via 3-hydroxyanthranilate in Pseudomonas fluorescens strain KU-7 journal September 2000
Active site of human liver aldehyde dehydrogenase journal September 1987
Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function journal December 2009
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Quinolinic acid in cerebrospinal fluid and serum in HIV-1 Infection: Relationship to clinical and neurological status journal February 1991
The Pyridine Ring of NAD Is Formed by a Nonenzymatic Pericyclic Reaction journal January 2005
Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion journal May 1997
Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques journal July 1998
Purification, Characterization, and Sequence Analysis of 2-Aminomuconic 6-Semialdehyde Dehydrogenase from Pseudomonas pseudoalcaligenes JS45 journal September 1998
Kynurenine pathway in major depression: Evidence of impaired neuroprotection journal February 2007
Aldehyde dehydrogenases: Widespread structural and functional diversity within a shared framework journal November 1993
The First Crystal Structure of a Thioacylenzyme Intermediate in the ALDH Family:  New Coenzyme Conformation and Relevance to Catalysis † journal March 2006
Correlated single-crystal electronic absorption spectroscopy and X-ray crystallography at NSLS beamline X26-C journal March 2011
Automated detection and centring of cryocooled protein crystals journal October 2006
Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex journal January 1998
Crystallographic evidence for active-site dynamics in the hydrolytic aldehyde dehydrogenases. Implications for the deacylation step of the catalyzed reaction journal May 2011
Coot model-building tools for molecular graphics journal November 2004
Coenzyme Isomerization Is Integral to Catalysis in Aldehyde Dehydrogenase † , ‡ journal June 2003
Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases journal December 1998
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
The First Crystal Structure of a Thioacylenzyme Intermediate in the ALDH Family:  New Coenzyme Conformation and Relevance to Catalysis journal August 2007
Kinetic and Spectroscopic Characterization of ACMSD from Pseudomonas fluorescens Reveals a Pentacoordinate Mononuclear Metallocofactor journal September 2005
Kynurenine pathway abnormalities in Parkinson's disease journal September 1992
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3-Hydroxykynurenine and Quinolinate: Pathogenic Synergism in Early Grade Huntington’s Disease? book January 2003
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Cited By (6)

What is the tryptophan kynurenine pathway and why is it important to neurotherapeutics? journal May 2015
Quaternary structure of α-amino-β-carboxymuconate-ϵ-semialdehyde decarboxylase (ACMSD) controls its activity journal June 2019
Combining X-ray and neutron crystallography with spectroscopy journal February 2017
NADP-Dependent Aldehyde Dehydrogenase from ArchaeonPyrobaculum sp.1860: Structural and Functional Features journal January 2016
Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism journal April 2018
The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S-bacillithiolation in Staphylococcus aureus journal May 2018

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
chemical sciences
biochemistry
chemical biology
physical chemistry