Synthesis of 2'-deoxy-2'-[.sup.18F]fluoro-5-methyl-1-B-D-arabinofuranosyluracil (.sup.18F-FMAU)
The present invention relates to methods of synthesizing .sup.18F-FMAU. In particular, .sup.18F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorporated into a fully automated cGMP-compliant radiosynthesis module, which results in a reduction in synthesis time and simplifies reaction conditions. The one-pot reaction conditions are also suitable for the production of 5-substituted thymidine or cytidine analogs. The products from the one-pot reaction (e.g. the labeled thymidine or cytidine analogs) can be used as probes for imaging tumor proliferative activity. More specifically, these [.sup.18F]-labeled thymidine or cytidine analogs can be used as a PET tracer for certain medical conditions, including, but not limited to, cancer disease, autoimmunity inflammation, and bone marrow transplant.
- Research Organization:
- Univ. of Southern California, Los Angeles, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- SC0002353
- Assignee:
- University of Southern California (Los Angeles, CA)
- Patent Number(s):
- 8,912,319
- Application Number:
- 13/183,924
- OSTI ID:
- 1165432
- Resource Relation:
- Patent File Date: 2011 Jul 15
- Country of Publication:
- United States
- Language:
- English
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