Microorganisms having enhanced tolerance to inhibitors and stress

Brown, Steven D.; Yang, Shihui

Title: Microorganisms having enhanced tolerance to inhibitors and stress

Patent · Tue Jul 29 00:00:00 EDT 2014

OSTI ID:1149918

Brown, Steven D.; Yang, Shihui

The present invention provides genetically modified strains of microorganisms that display enhanced tolerance to stress and/or inhibitors such as sodium acetate and vanillin. The enhanced tolerance can be achieved by increasing the expression of a protein of the Sm-like superfamily such as a bacterial Hfq protein and a fungal Sm or Lsm protein. Further, the present invention provides methods of producing alcohol from biomass materials by using the genetically modified microorganisms of the present invention.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-00OR22725

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Number(s):: 8,790,902

Application Number:: 13/589,709

OSTI ID:: 1149918

Country of Publication:: United States

Language:: English

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