Interactomes to Biological Phase Space: a call to begin thinking at a new level in computational biology.

Technical Report · Sat Sep 01 00:00:00 EDT 2007

DOI:https://doi.org/10.2172/1139978· OSTI ID:1139978

Davidson, George S.; Brown, William Michael

Techniques for high throughput determinations of interactomes, together with high resolution protein collocalizations maps within organelles and through membranes will soon create a vast resource. With these data, biological descriptions, akin to the high dimensional phase spaces familiar to physicists, will become possible. These descriptions will capture sufficient information to make possible realistic, system-level models of cells. The descriptions and the computational models they enable will require powerful computing techniques. This report is offered as a call to the computational biology community to begin thinking at this scale and as a challenge to develop the required algorithms and codes to make use of the new data.3

• Research Organization: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
• Sponsoring Organization: USDOE National Nuclear Security Administration (NNSA)
• DOE Contract Number: AC04-94AL85000
• OSTI ID: 1139978
• Report Number(s): SAND2007-6278; 520595
• Country of Publication: United States
• Language: English