skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Self-assembling peptide amphiphiles and related methods for growth factor delivery

Patent ·
OSTI ID:1107915

Amphiphilic peptide compounds comprising one or more epitope sequences for binding interaction with one or more corresponding growth factors, micellar assemblies of such compounds and related methods of use.

Research Organization:
Northwestern Univ., Evanston, IL (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-00ER45810
Assignee:
Northwestern University (Evanston, IL)
Patent Number(s):
8,580,923
Application Number:
13/423,310
OSTI ID:
1107915
Resource Relation:
Patent File Date: 2012 Mar 19
Country of Publication:
United States
Language:
English

References (339)

Control of Aragonite or Calcite Polymorphism by Mollusk Shell Macromolecules journal January 1996
Covalent capture of dynamic hydrogen-bonded assemblies journal January 2000
Structure and Dynamics of Peptide−Amphiphiles Incorporating Triple-Helical Proteinlike Molecular Architecture journal February 1999
Design of Tissue-engineered Nanoscaffold Through Self-assembly of Peptide Amphiphile journal July 2006
Peptide-based scaffolds for cartilage regeneration and methods for their use patent May 2013
Method for synthesizing organoapatites on to surgical metal alloys patent April 2000
Self-assembling amphiphiles for construction of peptide secondary structures patent August 2000
Surface coating spatially controlled patterns patent February 2005
Microlaser made of disordered media journal May 2000
Methods for automated essay analysis patent-application October 2002
Dynamics of the Lamellar−Cylindrical Transition in Weakly Segregated Diblock Copolymer Melts journal May 1997
Methods and compositions for encapsulation of cells patent-application November 2006
Control of crystal nucleation by patterned self-assembled monolayers journal April 1999
Biomimetic Synthesis of Macroscopic-Scale Calcium Carbonate Thin Films. Evidence for a Multistep Assembly Process journal November 1998
Self-assembly of peptide-amphiphile nanofibers under physiological conditions patent May 2008
Mapping the heparin-binding sites on type I collagen monomers and fibrils. journal June 1994
Calcium phosphate precipitation on the surface of HA-G-Ti composite under physiologic conditions journal January 1994
Hydrogels for Tissue Engineering journal July 2001
P. falciparum CS-peptides as universal T-cell epitope patent May 1992
Composition and method for self-assembly and mineralization of peptide amphiphiles patent June 2009
Derivatives of GLP-1 analogs patent October 2002
Peptide scaffold encapsulation of tissue cells and uses thereof patent-application October 2002
Synthesis of peptidylglycophospholipids, novel derivatives of muramyl-dipeptide journal January 1981
Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane. journal April 1993
Integrins and cardiovascular disease journal June 1998
Design of a Novel Fibronectin-Mimetic Peptide−Amphiphile for Functionalized Biomaterials journal March 2006
Modification of gelation kinetics in bioactive peptide amphiphiles journal December 2008
Membrane fusion induced by mutual interaction of the two charge-reversed amphiphilic peptides at neutral pH journal August 1991
Organoapatites: Materials for artificial bone. III. Biological testing journal March 1993
Biomaterials in Tissue Engineering journal June 1995
Organoapatites: Materials for artificial bone. II. Hardening reactions and properties journal March 1993
Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization. journal June 1985
Bioactivation of Metal Oxide Surfaces. 1. Surface Characterization and Cell Response journal September 1999
Mechanisms of Disease: what factors limit the success of peripheral nerve regeneration in humans? journal August 2006
Mimicry of natural material designs and processes journal June 1995
Microencapsulated islets as bioartificial endocrine pancreas journal November 1980
Delivery of human factor IX in mice by encapsulated recombinant myoblasts: a novel approach towards allogeneic gene therapy of hemophilia B journal June 1996
Vibrational Spectroscopy and Conformation of Peptides, Polypeptides, and Proteins book January 1986
Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor patent April 2003
Covalent Binding of Lipid to Protein: Diglyceride and Amide-Linked Fatty Acid at the N-Terminal End of the Murein-Lipoprotein of the Escherichia coli Outer Membrane journal April 1973
Formation of Helical Super Structure from Single-Walled Bilayers by Amphiphiles with Oligo-L-Glutamic Acid-Head Group journal October 1984
Matrix Elasticity Directs Stem Cell Lineage Specification journal August 2006
Design of an artificial four-helix bundle metalloprotein via a novel ruthenium(II)-assisted self-assembly process journal May 1992
Directional Neurite Outgrowth and Axonal Differentiation of Embryonic Hippocampal Neurons are Promoted by a Neurite Outgrowth Domain of the B2‐Chain of Laminin journal June 1996
The all-D-configuration segment containing the IKVAV sequence of laminin A chain has similar activities to the all-L-peptide in vitro and in vivo. journal July 1992
Angiogenesis: new aspects relating to its initiation and control journal January 1997
The basic science of gene therapy journal May 1993
Fast precipitation of calcium phosphate layers on titanium induced by simple chemical treatments journal January 1997
A surface-modified functional liposome capable of binding to cell membranes journal January 1999
X‐ray photoelectron spectroscopy applied to gold‐decorated mineral standards of biological interest journal April 1984
Self-Assembly of Giant Peptide Nanobelts journal March 2009
Locomotor Recovery in Spinal Cord-Injured Rats Treated with an Antibody Neutralizing the Myelin-Associated Neurite Growth Inhibitor Nogo-A journal May 2001
Control of crystal phase switching and orientation by soluble mollusc-shell proteins journal May 1996
The role of polar and facial amphipathic character in determining lipopolysaccharide-binding properties in synthetic cationic peptides journal June 2000
Design strategies in mineralized biological materials journal January 1997
Tissue engineering journal May 1993
Peptide/Protein Hybrid Materials: Enhanced Control of Structure and Improved Performance through Conjugation of Biological and Synthetic Polymers journal April 2004
Self-assembling properties of synthetic peptidic lipids journal April 1993
Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity patent November 1985
Lipopeptide stabilized microbubbles as diagnostic/therapeutic agents patent April 2003
Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins journal July 1996
The Significance of Artificial Cerebrospinal Fluid as Perfusate and Endoneurosurgery journal April 1996
Biomaterials Science book January 1996
Synthesis and structural investigations of N-alkylated β-peptidosulfonamide–peptide hybrids of the amyloidogenic amylin(20–29) sequence: implications of supramolecular folding for the design of peptide-based bionanomaterials journal January 2006
One- or multi-layered layer elements applied to supports and their production patent May 1993
Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof patent-application September 2005
Biodegradation and biocompatibility of PLA and PLGA microspheres journal October 1997
Controllable Orientation of the Peptide-Based Surfactant at Air-Water Interface journal May 1997
Microcontact Printing for Precise Control of Nerve Cell Growth in Culture journal February 1999
Information retrieval using dynamic evidence combination patent July 2001
Soft-Tissue Augmentation with Injectable Alginate and Syngeneic Fibroblasts journal January 2000
Plasma sprayed coatings of hydroxylapatite journal December 1987
Cadmium-Induced Toxicity in Rat Primary Mid-brain Neuroglia Cultures: Role of Oxidative Stress from Microglia journal April 2007
Plasma sprayed hydroxyapatite coatings on titanium substrates Part 2: optimisation of coating properties journal November 1998
THE MATERIAL BONE: Structure-Mechanical Function Relations journal August 1998
Neural Stem and Progenitor Cells: A Strategy for Gene Therapy and Brain Repair journal April 1998
Recent advances in multiple antigen peptides journal January 1996
A Novel, Quantitative Model for Study of Endothelial Cell Migration and Sprout Formation within Three-Dimensional Collagen Matrices journal March 1999
Hydroxylapatite coating of porous implants improves bone ingrowth and interface attachment strength journal August 1992
Structural arrangements at the interface between plasma sprayed calcium phosphates and bone journal June 1994
The Specification of Dorsal cell Fates in the Vertebrate Central Nervous System journal March 1999
Calcium phosphate plasma-sprayed coatings and their stability: Anin vivo study journal August 1994
Octacalcium Phosphate and Hydroxyapatite: Crystal Structure of Octacalcium Phosphate journal December 1962
Endothelial cell–mediated type I collagen gel contraction is regulated by hemin journal August 2000
Directed evolution of novel binding proteins patent June 1993
Bone marrow cells regenerate infarcted myocardium journal April 2001
Therapeutic Interventions Following Mammalian Spinal Cord Injury journal May 2001
Self-Assembled Peptide Amphiphile Nanofibers Conjugated to MRI Contrast Agents journal January 2005
Conformation and dynamics of heparin and heparan sulfate journal November 2000
Encapsulation of nanotubes via self-assembled nanostructures patent May 2005
Responsive gels formed by the spontaneous self-assembly of peptides into polymeric β-sheet tapes journal March 1997
Progress toward human gene therapy journal June 1989
Branched peptide-amphiphiles as self-assembling coatings for tissue engineering scaffolds journal July 2006
Covalent Attachment of Cell-Adhesive, (Arg-Gly-Asp)-Containing Peptides to Titanium Surfaces journal September 1998
Block copolymers for multifunctional self-assembled systems patent-application March 2003
Crosslinked micellar gel composition patent September 2002
Development of fibrin derivatives for controlled release of heparin-binding growth factors journal April 2000
Cell seeding in porous transplantation devices journal January 1993
Neural injury repair: hope for the future as barriers to effective CNS regeneration become clearer journal January 1995
Room-Temperature Ultraviolet Nanowire Nanolasers journal June 2001
Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation. journal August 1988
Properties of the (DSS) n triplet repeat domain of rat dentin phosphophoryn journal January 1998
The N-terminal Sequence (Residues 1–65) Is Essential for Dimerization, Activities, and Peptide Binding of Escherichia coli DsbC journal May 2000
The Process of Physical Weakening and Dissolution of the HA-coated Implant in Bone and Soft Tissue journal June 1998
Self-assembling peptide amphiphile nanofiber matrices for cell entrapment journal July 2005
Coassembly of Amphiphiles with Opposite Peptide Polarities into Nanofibers journal February 2005
Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization journal September 2000
High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells journal April 1987
Injectable Alginate Seeded with Chondrocytes as a Potential Treatment for Vesicoureteral Reflux journal August 1993
Modulated Supramolecular Assemblies Composed of Tripeptide Derivatives:  Formation of Micrometer-Scale Rods, Nanometer-Size Needles, and Regular Patterns with Molecular-Level Flatness from the Same Compound journal May 2000
The effect of hydroxyapatite coating on bone growth into porous titanium alloy implants journal March 1989
The Carboxyl-terminal Domain of Phosphophoryn Contains Unique Extended Triplet Amino Acid Repeat Sequences Forming Ordered Carboxyl-Phosphate Interaction Ridges That May Be Essential in the Biomineralization Process journal December 1996
Biomimetic Growth of Hydroxyapatite on Gelatin Films Doped with Sodium Polyacrylate journal December 2000
Charge induced pattern formation on surfaces: Segregation in cylindrical micelles of cationic-anionic peptide-amphiphiles journal February 2005
Covalent linkage of a synthetic peptide to a fluorescent phospholipid and its incorporation into supported phospholipid monolayers journal April 1984
The low temperature formation of octacalcium phosphate journal September 1993
Progenitor Cell Biology: Implications for Neural Regeneration journal July 1999
Transparent barrier coatings exhibiting reduced thin film interference patent December 1998
Oriented growth of phosphates on polycrystalline titanium in a process mimicking biomineralization journal November 1999
Processes for producing collagen matrixes and methods of using same patent May 1992
Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures journal June 1992
Molecular monolayer rods and tubules made of .alpha.-(L-lysine),.omega.-(amino) bolaamphiphiles journal February 1993
Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor patent September 1999
Engineering of peptide β-sheet nanotapes journal January 1997
Enzyme-Mediated Degradation of Peptide-Amphiphile Nanofiber Networks journal November 2005
Modulation of Fluorescence through Coassembly of Molecules in Organic Nanostructures journal January 2007
beta-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin. journal November 1993
Bonelike apatite coating on organic polymers: novel nucleation process using sodium silicate solution journal May 1999
Information processing expert system for text analysis and predicting public opinion based information available to the public patent May 1990
Functionalized nanocrystals and their use in detection systems patent September 2000
Differentiation of adipose stromal cells into osteoblasts and uses thereof patent May 2002
Electrostatically-Directed Self-Assembly of Cylindrical Peptide Amphiphile Nanostructures journal July 2004
Stabilization of Peptide Fibrils by Hydrophobic Interaction journal February 2007
Cellular recognition of synthetic peptide amphiphiles in self-assembled monolayer films journal December 1999
Bone structure: from ångstroms to microns journal February 1992
Heparin-induced Self-association of Fibroblast Growth Factor-2: EVIDENCE FOR TWO OLIGOMERIZATION PROCESSES journal June 1997
Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord journal December 1999
Peptide amphiphiles having improved solubility and methods of using same patent December 2011
Isolation, Characterization, and use of Stem Cells from the CNS journal March 1995
Multilineage Potential of Adult Human Mesenchymal Stem Cells journal April 1999
In vitro and in vivo degradation of porous poly(dl-lactic-co-glycolic acid) foams journal September 2000
Nitric Oxide and Apoptosis: Another Paradigm for the Double-Edged Role of Nitric Oxide journal August 1997
Three-dimensional ordered distribution of crystals in turkey tendon collagen fibers. journal December 1989
Self-Assembling Amphiphilic Siderophores from Marine Bacteria journal February 2000
Tissue factor methods and compositions for coagulation and tumor treatment patent December 2000
Wound tissue can utilize a polymeric template to synthesize a functional extension of skin journal January 1982
Heparin Binding Nanostructures to Promote Growth of Blood Vessels journal September 2006
Induction of protein-like molecular architecture by self-assembly processes journal January 1999
Intermolecular Forces in the Self-Assembly of Peptide Amphiphile Nanofibers journal March 2006
General approach to the synthesis of short .alpha.-helical peptides journal November 1991
Molecular Modelling of a Multiphosphorylated Sequence Motif Bound to Hydroxyapatite Surfaces journal February 2000
New coupling reagents in peptide chemistry journal January 1989
Differences in the Interaction of Heparin with Arginine and Lysine and the Importance of these Basic Amino Acids in the Binding of Heparin to Acidic Fibroblast Growth Factor journal November 1995
Chemical Attachment of Polystyrene- block -poly(methacrylic acid) Micelles on a Silicon Nitride Surface journal January 1996
Reversible Hydrogels from Self-Assembling Artificial Proteins journal July 1998
Synthesis and self-assembly of ABC triblock bola peptide amphiphiles patent March 2010
Template mineralization of self-assembled anisotropic lipid microstructures journal July 1993
Minimal Lipidation Stabilizes Protein-Like Molecular Architecture journal October 1998
Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus journal March 1977
Method and system for topical segmentation, segment significance and segment function patent October 2002
Molecular Self-Assembly of Peptide Nanostructures: Mechanism of Association and Potential Uses journal May 2006
Therapeutic compounds comprised of anti-Fc receptor antibodies patent August 2001
In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices. journal November 1983
Physicochemical aspects of drug delivery and release from polymer-based colloids journal March 2000
Folic Acid as a Growth-Factor for the Rat journal December 1950
Self-assembly and applications of biomimetic and bioactive peptide-amphiphiles journal January 2006
Comparison of cultured and uncultured keratinocytes seeded into a collagen–GAG matrix for skin replacements journal March 1999
Self-Assembly of a β-Sheet Protein Governed by Relief of Electrostatic Repulsion Relative to van der Waals Attraction journal December 2000
Molecular Manipulation of Microstructures: Biomaterials, Ceramics, and Semiconductors journal August 1997
Modulation of cell adhesion by modification of titanium surfaces with covalently attached self-assembled monolayers journal October 1990
Self-Assembly of Peptide−Amphiphile Nanofibers:  The Roles of Hydrogen Bonding and Amphiphilic Packing journal June 2006
Self-assembly of peptide-amphiphile nanofibers under physiological conditions patent-application January 2004
Biomimetic Mineralization of Collagen by Combined Fibril Assembly and Calcium Phosphate Formation journal October 1999
Method and system for verifying accuracy of spelling and grammatical composition of a document patent July 2000
Organoapatites: Materials for artificial bone. I. Synthesis and microstructure journal February 1992
Vacuum ultraviolet circular dichroism of protected homooligomers derived from L-leucine journal March 1977
Synthetic lipidation of peptides and amino acids: monolayer structure and properties. journal September 1995
Surface modifications for enhanced epithelialization patent-application January 2002
Vascularized Collagen-Glycosaminoglycan Matrix Provides a Dermal Substrate and Improves Take of Cultured Epithelial Autografts journal January 1998
Angiopoietin-1 and Its Receptor Tie-2 Participate in the Regulation of Capillary-like Tubule Formation and Survival of Endothelial Cells journal November 1999
Dentifrice patent July 1992
Aggregation behavior of synthetic peptide lipids with arginine in aqueous solution and construction of a vitamin B12 artificial enzyme journal September 2000
Synthesis and properties of hydroxyapatite/poly-?-lactide composite biomaterials journal May 1999
Random laser action in ZnO journal August 2000
Solid-state foaming of titanium by superplastic expansion of argon-filled pores journal May 2001
Protection of a Decapeptide from Proteolytic Cleavage by Lipidation and Self-Assembly into High-Axial-Ratio Microstructures:  A Kinetic and Structural Study journal August 1999
Amphiphilic macrocyclic derivatives and their analogues patent-application May 2003
Formation and Structure of Self-Assembled Monolayers journal January 1996
Multiblock biodegradable hydrogels for drug delivery and tissue treatment patent March 2001
Structure of the stable and metastable ripple phase of dipalmitoylphosphatidylcholine journal January 1996
Vacuum ultraviolet circular dichroism of .beta.-forming alkyl oligopeptides journal June 1976
Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon patent June 2008
Influence of monosaccharides and related molecules on the morphology of hydroxyapatite journal October 1993
Enhanced angiogenesis through controlled release of basic fibroblast growth factor from peptide amphiphile for tissue regeneration journal December 2006
Methods and materials for nanocrystalline surface coatings and attachment of peptide amphiphile nanofibers thereon patent-application December 2004
Spatial organization and patterning of gold nanoparticles on self-assembled biolipid tubular templates journal January 1996
Myogenic Expression of Mesenchymal Stem Cells within Myotubes of mdx Mice in Vitro and in Vivo journal December 1995
Computed circular dichroism spectra for the evaluation of protein conformation journal October 1969
Wetting of poly(l-lactic acid) and poly(dl-lactic-co-glycolic acid) foams for tissue culture journal January 1994
Effects of Ischemia on Ulcer Wound Healing: A New Model in the Rabbit Ear journal January 1990
Biomineralization: the form(id)able part of bioinorganic chemistry! * journal January 1997
Trifluoroacetate, a contaminant in purified proteins, inhibits proliferation of osteoblasts and chondrocytes journal November 1999
All-Atom Numerical Studies of Self-Assembly of Zwitterionic Peptide Amphiphiles journal September 2004
Encapsulation of pyrene within self-assembled peptide amphiphile nanofibers journal January 2005
Optical processes in ZnO journal December 1995
Nanostructured Polymer Duplexes via the Covalent Casting of 1-Dimensional H-Bonding Motifs:  A New Strategy for the Self-Assembly of Macromolecular Precursors journal May 2000
Diverse mechanisms of osteoblast spreading on hydroxyapatite and titanium journal June 2000
Nanotechnology approaches for the regeneration and neuroprotection of the central nervous system journal April 2005
Magnetic Resonance Imaging of Self-Assembled Biomaterial Scaffolds journal November 2005
Synthesis of palmitoylated Ras-peptides and -proteins journal October 2006
Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor patent October 2004
[26] Construction of biologically active protein molecular architecture using self-assembling peptide-amphiphiles book January 1997
Probing the Interior of Peptide Amphiphile Supramolecular Aggregates journal May 2005
Coating of Surfaces with Stabilized Reactive Micelles from Poly(ethylene glycol)−Poly( dl -lactic acid) Block Copolymer journal August 1999
Synthesis and Physicochemical Characterization of Cyclic Laminin Related Peptides journal June 1998
Self-assembling peptide amphiphiles and related methods for growth factor delivery patent March 2012
Axons from CNS neurones regenerate into PNS grafts journal March 1980
Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof patent November 2008
Bioactive nanocrystalline sol-gel hydroxyapatite coatings journal January 1999
Self-assembly and mineralization of peptide-amphiphile nanofibers patent November 2010
The shear strength and the failure mode of plasma-sprayed hydroxyapatite coating to bone: The effect of coating thickness journal October 1993
Organization of 'nanocrystal molecules' using DNA journal August 1996
Differentiation of human embryonic germ cells patent May 2003
In Vitro Models of Vasculogenesis and Angiogenesis journal April 2001
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule journal May 1984
Angiogenic heparin-binding epitopes, peptide amphiphiles, self-assembled compositions and related methods of use patent December 2010
Comparative analysis of structurally defined heparin binding sequences reveals a distinct spatial distribution of basic residues. journal September 1993
Self-assembly and mineralization of peptide-amphiphile nanofibers patent February 2009
Modification of surfaces by covalent attachment of polymer micelles journal April 1999
Bone morphogenetic proteins in human bone regeneration journal January 2000
Self-Assembly of Model DNA-Binding Peptide Amphiphiles journal December 2005
Intralayer hydrogen-bond-directed self-assembly of nano-fibers from dicarboxylic valylvaline bolaamphiphiles journal January 1998
Regulation of β-Sheet Structures within Amyloid-Like β-Sheet Assemblage from Tripeptide Derivatives journal December 1998
Calcium Phosphate Phase Identification Using XPS and Time-of-Flight Cluster SIMS journal January 1999
Vascular Endothelial Growth Factor Is More Important Than Basic Fibroblastic Growth Factor During Ischemic Wound Healing journal February 1999
Involvement of α7β1 integrin in the conditioning-lesion effect on sensory axon regeneration journal March 2003
Methods for treatment or prevention of neurodegenerative conditions using immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core patent February 1999
CdS mineralization of hexagonal, lamellar, and cubic lyotropic liquid crystals journal February 1999
Conformational behavior of ionic self-complementary peptides journal January 2000
Octacalcium phosphate. 3. Infrared and Raman vibrational spectra journal October 1993
Transmission Spectra of ZnO Single Crystals journal January 1968
Phage Display journal April 1997
Prophylaxis and therapy of acquired immunodeficiency syndrome patent July 2001
A behavioral and anatomical analysis of spinal cord injury produced by a feedback-controlled impaction device journal March 1987
Self-assembled peptide fibers from valylvaline bola-amphiphiles by a parallel β-sheet network journal July 2000
Supramolecular nanostructures that mimic VEGF as a strategy for ischemic tissue repair journal August 2011
Graded Histological and Locomotor Outcomes after Spinal Cord Contusion Using the NYU Weight-Drop Device versus Transection journal June 1996
Presentation of RGDS Epitopes on Self-Assembled Nanofibers of Branched Peptide Amphiphiles journal June 2006
Random Laser Action in Semiconductor Powder journal March 1999
Novel approach to fabricate porous sponges of poly(d,l-lactic-co-glycolic acid) without the use of organic solvents journal July 1996
Structure-activity study of a laminin α1 chain active peptide segment Ile-Lys-Val-Ala-Val (IKVAV) journal May 1995
Plasma membrane: rapid isolation and exposure of the cytoplasmic surface by use of positively charged beads journal January 1977
On the Structure and Stability of Self-Assembled Zwitterionic Peptide Amphiphiles:  A Theoretical Study journal March 2004
Giant Wormlike Rubber Micelles journal February 1999
Composition and method for self-assembly and mineralizatin of peptide amphiphiles patent-application July 2006
Method of identifying molecules that home to a selected organ in vivo patent April 1997
Self-complementary oligopeptide matrices support mammalian cell attachment journal December 1995
Excitonic ultraviolet laser emission at room temperature from naturally made cavity in ZnO nanocrytal thin films journal November 1998
Design of Peptides with High Affinities for Heparin and Endothelial Cell Proteoglycans journal March 2000
Encapsulation of Carbon Nanotubes by Self-Assembling Peptide Amphiphiles journal May 2005
Thermotropic mesophases of ionic amphiphiles: II. Ionic amphiphiles in aqueous media journal November 1994
Biomaterials in Drug Delivery and Tissue Engineering:  One Laboratory's Experience journal February 2000
Semiconductor-Encapsulated Peptide−Amphiphile Nanofibers journal October 2004
Effect of chirality on the formation of tubules from glycolipidic amphiphiles journal March 1996
Self-assembled peptide-amphiphiles & self-assembled peptide nanofiber networks presenting multiple signals patent-application December 2005
Polysaccharide strong and weak gels journal August 1993
Effects of GDNF on Axotomized Sensory and Motor Neurons in Adult Rats journal June 1997
Myogenic cells derived from rat bone marrow mesenchymal stem cells exposed to 5-azacytidine journal December 1995
In VitroChondrogenesis of Bone Marrow-Derived Mesenchymal Progenitor Cells journal January 1998
Selection of peptides with semiconductor binding specificity for directed nanocrystal assembly journal June 2000
Controlled release of nerve growth factor from a heparin-containing fibrin-based cell ingrowth matrix journal October 2000
The Carboxyl-terminal Domain(111165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency journal March 1996
Compositions and methods for controlling stem cell and tumor cell differentiation, growth, and formation patent-application September 2005
A method to attach lectins to the surface of spermine alginate microcapsules based on the avidin biotin interaction journal January 1996
Molecular modeling of protein-glycosaminoglycan interactions. journal January 1989
Organization of hydroxyapatite crystals within collagen fibrils journal October 1986
Determination of protein secondary structure by Fourier transform infrared spectroscopy: A critical assessment journal January 1993
Alginate hydrogels as synthetic extracellular matrix materials journal January 1999
Encapsulation of nanotubes via self-assembled nanostructures patent-application February 2004
Synthetic Bilayer Membranes: Molecular Design, Self-Organization, and Application journal June 1992
Nano-fibrous scaffolds for tissue engineering journal December 2004
Self-assembling peptide amphiphiles and related methods for growth factor delivery patent June 2009
A Transmission Electron Microscope Study Using Vitrified Ice Sections of Predentin: Structural Changes in the Dentin Collagenous Matrix prior to Mineralization journal December 2000
Poly(amino acid) adhesive tissue grafts patent March 1998
A general method for preparation of peptides biotinylated at the carboxy terminus journal April 1992
Modulation of crystal formation by bone phosphoproteins: role of glutamic acid-rich sequences in the nucleation of hydroxyapatite by bone sialoprotein journal August 1994
Full-Length Plant CDNA and Uses Thereof patent-application June 2006
Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor patent September 1997
Preparation of the very acid-sensitive Fmoc-Lys(Mtt)-OH Application in the synthesis of side-chain to side-chain cyclic peptides and oligolysine cores suitable for the solid-phase assembly of MAPs and TASPs journal May 1995
The relative magnitudes of endothelial force generation and matrix stiffness modulate capillary morphogenesis in vitro journal July 2004
Design and Application of Self-Assembled Low Molecular Weight Hydrogels journal September 2005
Composition and method for self-assembly and mineralization of peptide-amphiphiles patent February 2012
Charged peptide-amphiphile solutions and self-assembled peptide nanofiber networks formed therefrom patent May 2009
Effect of proteoglycans on in vitro hydroxyapatite formation journal December 1979
Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors journal January 1990
Process for nucleation of ceramics and product thereof patent November 1999
Discourse parsing and summarization patent-application April 2002
Excitonic gain and stimulated ultraviolet emission in nanocrystalline zinc-oxide powder journal October 2000
Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers journal February 2004
Conversion of Supramolecular Clusters to Macromolecular Objects journal January 1999
Semiconductor Clusters, Nanocrystals, and Quantum Dots journal February 1996
Phospholipid vesicles as a model system for biomineralization journal December 1986
Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2. journal December 1997
Transplants of Fibroblasts Genetically Modified to Express BDNF Promote Regeneration of Adult Rat Rubrospinal Axons and Recovery of Forelimb Function journal June 1999
Self-assembling Peptide Amphiphiles and Related Methods for Growth Factor Delivery patent-application September 2005
Devices and methods for mixing and extruding medically useful compositions patent-application April 2004
Electrochemical Nucleation of Gold Nanoparticles in a Polymer Film at a Liquid−Liquid Interface journal February 2005
Hydrophilicity of Polar and Apolar Domains of Amphiphiles journal September 2000
Mechanism for the Enhanced Diffusion of Charged Oxygen Ions in SiO 2 journal February 2001
Methionine containing animal cell culture medium and its use patent October 2001
Self-assembly of peptide-amphiphile nanofibers under physiological conditions patent June 2010
Alginate based new materials journal August 1997
Epitope Identification and Discovery Using Phage Display Libraries: Applications in Vaccine Development and Diagnostics journal January 2004
Dicarboxylic Oligopeptide Bolaamphiphiles:  Proton-Triggered Self-Assembly of Microtubes with Loose Solid Surfaces journal September 1998
Review: tissue engineering for regeneration of articular cartilage journal March 2000
Control and Design Principles in Biological Mineralization journal February 1992
Self-Assembling Amphiphiles for Construction of Protein Molecular Architecture journal January 1996
Noncovalent Formation of Polyglycine II-Type Structure by Hexagonal Self-Assembly of Linear Polymolecular Chains journal July 1997
Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells journal October 2000
Self-assembly and mineralization of peptide-amphiphile nanofibers patent-application January 2004
Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds journal June 2000
Primate embryonic stem cells patent December 1998
Functional Arteries Grown in Vitro journal April 1999
Interfacial bond strength of electrophoretically deposited hydroxyapatite coatings on metals journal January 1999
The Effects of Titanium and Hydroxyapatite on Osteoblastic Expression and Proliferation in Rat Parietal Bone Cultures journal June 1993
Self-assembly of peptide-amphiphile nanofibers under physiological conditions patent November 2011
Method for coating medical implants patent March 2001
Enhanced Oligonucleotide Binding to Self-Assembled Nanofibers journal May 2005
System and method for computer-based automatic essay scoring patent January 2001
Highly Porous Polymer Matrices as a Three-Dimensional Culture System for Hepatocytes journal September 1997
Presentation and Recognition of Biotin on Nanofibers Formed by Branched Peptide Amphiphiles journal February 2005
Hydroxyapatite-Coated Titanium for Orthopedic Implant Applications journal January 1988
Human dentin phosphophoryn nucleotide and amino acid sequence journal December 1998
Two-Dimensional Order in β-Sheet Peptide Monolayers journal December 2000
Cross-Linking Exogenous Bifunctional Peptides into Fibrin Gels with Factor XIIIa journal January 1999
Surfactant peptide nanostructures, and uses thereof patent-application September 2003
Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction journal October 1981
Small Neuroscience: The Nanostructure of the Central Nervous System and Emerging Nanotechnology Applications journal November 2005
Self-assembling Peptide Scaffolds Promote Enamel Remineralization journal May 2007