Systems and methods for modeling and analyzing networks

Patent · Tue Oct 29 00:00:00 EDT 2013

OSTI ID:1107627

Hill, Colin C; Church, Bruce W; McDonagh, Paul D; Khalil, Iya G; Neyarapally, Thomas A; Pitluk, Zachary W

The systems and methods described herein utilize a probabilistic modeling framework for reverse engineering an ensemble of causal models, from data and then forward simulating the ensemble of models to analyze and predict the behavior of the network. In certain embodiments, the systems and methods described herein include data-driven techniques for developing causal models for biological networks. Causal network models include computational representations of the causal relationships between independent variables such as a compound of interest and dependent variables such as measured DNA alterations, changes in mRNA, protein, and metabolites to phenotypic readouts of efficacy and toxicity.

• Research Organization: Gene Network Sciences, Inc. (Cambridge, MA)
• Sponsoring Organization: USDOE
• DOE Contract Number: FG02-04ER63806
• Assignee: Gene Network Sciences, Inc. (Cambridge, MA)
• Patent Number(s): 8,571,803
• Application Number: 11/985,618
• OSTI ID: 1107627
• Country of Publication: United States
• Language: English

Related Subjects

97 MATHEMATICS AND COMPUTING