Visual-servoing optical microscopy

Callahan, Daniel E; Parvin, Bahram

Title: Visual-servoing optical microscopy

Patent · Tue Oct 01 00:00:00 EDT 2013

OSTI ID:1107355

Callahan, Daniel E; Parvin, Bahram

The present invention provides methods and devices for the knowledge-based discovery and optimization of differences between cell types. In particular, the present invention provides visual servoing optical microscopy, as well as analysis methods. The present invention provides means for the close monitoring of hundreds of individual, living cells over time; quantification of dynamic physiological responses in multiple channels; real-time digital image segmentation and analysis; intelligent, repetitive computer-applied cell stress and cell stimulation; and the ability to return to the same field of cells for long-term studies and observation. The present invention further provides means to optimize culture conditions for specific subpopulations of cells.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC03-76SF00098

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 8,548,745

Application Number:: 13/107,601

OSTI ID:: 1107355

Country of Publication:: United States

Language:: English

References (12)

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