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Title: Diagnosis and assessment of skeletal related disease using calcium 41

Abstract

A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope .sup.41Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope .sup.41Ca by the patient, obtaining a sample of the radioactive calcium isotope .sup.41Ca from the patient, isolating the calcium content of the sample in a form suitable for precise measurement of isotopic calcium concentrations, and measuring the calcium content to determine parameters of calcium metabolism in the patient.

Inventors:
; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1083465
Patent Number(s):
8,388,930
Application Number:
13/448,045
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY

Citation Formats

Hillegonds, Darren J., Vogel, John S., Fitzgerald, Robert L., Deftos, Leonard J., Herold, David, and Burton, Douglas W. Diagnosis and assessment of skeletal related disease using calcium 41. United States: N. p., 2013. Web.
Hillegonds, Darren J., Vogel, John S., Fitzgerald, Robert L., Deftos, Leonard J., Herold, David, & Burton, Douglas W. Diagnosis and assessment of skeletal related disease using calcium 41. United States.
Hillegonds, Darren J., Vogel, John S., Fitzgerald, Robert L., Deftos, Leonard J., Herold, David, and Burton, Douglas W. 2013. "Diagnosis and assessment of skeletal related disease using calcium 41". United States. https://www.osti.gov/servlets/purl/1083465.
@article{osti_1083465,
title = {Diagnosis and assessment of skeletal related disease using calcium 41},
author = {Hillegonds, Darren J. and Vogel, John S. and Fitzgerald, Robert L. and Deftos, Leonard J. and Herold, David and Burton, Douglas W.},
abstractNote = {A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope .sup.41Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope .sup.41Ca by the patient, obtaining a sample of the radioactive calcium isotope .sup.41Ca from the patient, isolating the calcium content of the sample in a form suitable for precise measurement of isotopic calcium concentrations, and measuring the calcium content to determine parameters of calcium metabolism in the patient.},
doi = {},
url = {https://www.osti.gov/biblio/1083465}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 05 00:00:00 EST 2013},
month = {Tue Mar 05 00:00:00 EST 2013}
}

Works referenced in this record:

Calcium-41 as a long-term biological tracer for bone resorption
journal, December 1990

  • Elmore, David; Bhattacharyya, Maryka H.; Sacco-Gibson, Nancy
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 52, Issue 3-4
  • https://doi.org/10.1016/0168-583X(90)90471-6

Method of measurement in biological systems
patent, December 1994


Protocol for assessing bone health in humans by tracing long-lived 41Ca isotope in urine, serum, and saliva samples
journal, September 2004


Method of measurement in biological systems
patent, May 1993


41Ca and Accelerator Mass Spectrometry to Monitor Calcium Metabolism in End Stage Renal Disease Patients
journal, November 2005


The study of skeletal calcium metabolism with 41Ca and 45Ca
journal, October 2000

  • Freeman, Stewart P. H. T.; Beck, Belinda; Bierman, June M.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 172, Issue 1-4
  • https://doi.org/10.1016/S0168-583X(00)00341-4

Method for detection of long-lived radioisotopes in small biochemical samples
patent, November 1994


Human calcium metabolism including bone resorption measured with 41Ca tracer
journal, March 1997

  • Freeman, Stewart P. H. T.; King, Janet C.; Vieira, Nancy E.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 123, Issue 1-4
  • https://doi.org/10.1016/S0168-583X(96)00701-X

Calcium resorption from bone in a human studied by 41Ca tracing
journal, June 1994


Preparation of 41Ca AMS standards
journal, October 2000

  • Nishiizumi, Kunihiko; Caffee, Marc W.; DePaolo, Donald J.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 172, Issue 1-4
  • https://doi.org/10.1016/S0168-583X(00)00150-6

Biological sample preparation and 41Ca AMS measurement at LLNL
journal, May 1995

  • Freeman, S. P. H. T.; Serfass, R. E.; King, J. C.
  • Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, Vol. 99, Issue 1-4
  • https://doi.org/10.1016/0168-583X(95)00342-8

Techniques: The application of accelerator mass spectrometry to pharmacology and toxicology
journal, August 2004