Expanding the eukaryotic genetic code

Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher; Schultz, Peter G.

Title: Expanding the eukaryotic genetic code

Patent · Tue Jan 22 00:00:00 EST 2013

OSTI ID:1082728

Chin, Jason W.; Cropp, T. Ashton; Anderson, J. Christopher; Schultz, Peter G.

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

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Research Organization:: The Scripps Research Inst., La Jolla, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG03-00ER45812

Assignee:: The Scripps Research Institute (La Jolla, CA)

Patent Number(s):: 8,357,532

Application Number:: 13/443,800

OSTI ID:: 1082728

Country of Publication:: United States

Language:: English

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