In Vivo Behavior of Genetically Engineered Herpes Simplex Viruses R7017 and R7020. II. Studies in Immunocompetent and Immunosuppressed Owl Monkeys (Aotus trivirgatus)
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journal
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August 1990 |
Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4.
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journal
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January 1985 |
Death of serum-free mouse embryo cells caused by epidermal growth factor deprivation.
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journal
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May 1991 |
Programmed cell death: Apoptosis and oncogenesis
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journal
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June 1991 |
Expression of hepatitis B virus S gene by herpes simplex virus type 1 vectors carrying alpha- and beta-regulated gene chimeras.
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journal
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September 1984 |
Human male germ cell tumor resistance to cisplatin is linked to TP53 gene mutation
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journal
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May 1998 |
Herpes simplex virus neurovirulence and productive infection of neural cells is associated with a function which maps between 0.82 and 0.832 map units on the hsv genome
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journal
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October 1989 |
ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
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journal
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June 1997 |
Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence
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journal
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March 1991 |
Activation of Epstein–Barr virus latent genes protects human B cells from death by apoptosis
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journal
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February 1991 |
Sequences of the bovine herpesvims 1 homologue of herpes simplex virus type-1 α-trans-inducing factor (UL48)
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journal
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October 1992 |
Rescue of a herpes simplex virus type 1 neurovirulence function with a cloned DNA fragment.
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journal
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January 1985 |
Sequence of MyD116 cDNA: a novel myeloid differentiation primary response gene induced by IL6
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journal
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January 1990 |
Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
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journal
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December 1997 |
Transfer of Genes to Humans: Early Lessons and Obstacles to Success
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journal
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October 1995 |
The Herpes Simplex Virus Type 2 (HG52) Variant JH2604 Has a 1488 bp Deletion which Eliminates Neurovirulence in Mice
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journal
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November 1989 |
Functional domains within the a sequence involved in the cleavage-packaging of herpes simplex virus DNA.
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journal
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January 1986 |
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes.
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journal
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January 1982 |
The DNA Sequences of the Long Repeat Region and Adjoining Parts of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1
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journal
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November 1988 |
Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models.
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journal
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June 1993 |
Characterization of herpes simplex virus 1 alpha proteins 0, 4, and 27 with monoclonal antibodies.
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journal
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January 1984 |
The basic science of gene therapy
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journal
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May 1993 |
Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences as BamHI fragments.
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journal
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July 1980 |
Size, Composition, and Structure of the Deoxyribonucleic Acid of Herpes Simplex Virus Subtypes 1 and 2
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journal
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January 1971 |
The RL neurovirulence locus in herpes simplex virus type 2 strain HG52 plays no role in latency
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journal
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September 1991 |
Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins
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journal
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January 1998 |
Why do neurons die when deprived of trophic factor?
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journal
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September 1989 |
In Vivo Behavior of Genetically Engineered Herpes Simplex Viruses R7017 and R7020: Construction and Evaluation in Rodents
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journal
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September 1988 |
A noninverting genome of a viable herpes simplex virus 1: presence of head-to-tail linkages in packaged genomes and requirements for circularization after infection.
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journal
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January 1985 |
Mapping of functional and antigenic domains of the alpha 4 protein of herpes simplex virus 1.
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journal
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January 1988 |
Restoration of Wild-type Pathogenicity to an Attenuated DNA Polymerase Mutant of Herpes Simplex Virus Type 1
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journal
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November 1986 |
Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity.
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journal
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October 1991 |
Serial passage of embryonic human astrocytes in serum-free, hormone-supplemented medium
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journal
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January 1991 |
Functional and molecular analyses of the avirulent wild-type herpes simplex virus type 1 strain KOS.
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journal
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January 1986 |
p53 status and the efficacy of cancer therapy in vivo
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journal
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November 1994 |
Structure and role of the herpes simplex virus DNA termini in inversion, circularization and generation of virion DNA
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November 1982 |
Characterization of Herpes Simplex Virus Strains Differing in their Effects on Social Behaviour of Infected Cells
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May 1968 |
2021 Enhanced replication of attenuated HSV-1 in irradiated human glioma xenografts
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journal
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January 1997 |
Cell suicide: by ICE, not fire
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journal
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February 1994 |
The Complete DNA Sequence of the Long Unique Region in the Genome of Herpes Simplex Virus Type 1
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journal
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July 1988 |
Vaccine potential of a live avirulent herpes simplex virus
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journal
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August 1986 |
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
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journal
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June 1992 |
Characterization of a viable, noninverting herpes simplex virus 1 genome derived by insertion and deletion of sequences at the junction of components L and S.
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journal
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May 1983 |
Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1.
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journal
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November 1995 |
Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors
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journal
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February 1998 |
Application of Denatured, Electrophoretically Separated, and Immobilized Lysates of Herpes Simplex Virus-Infected Cells for Detection of Monoclonal Antibodies and for Studies of the Properties of Viral Proteins
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journal
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January 1983 |
Signals for site-specific cleavage of HSV DNA: maturation involves two separate cleavage events at sites distal to the recognition sequences
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journal
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July 1985 |
Complete DNA sequence of the short repeat region in the genome of herpes simplex virus type 1
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journal
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January 1986 |
Enhancement of Gene Therapy Specificity for Diffuse Colon Carcinoma Liver Metastases with Recombinant Herpes Simplex Virus
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journal
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January 1996 |
Site-specific cleavage/packaging of herpes simplex virus DNA and the selective maturation of nucleocapsids containing full-length viral DNA
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journal
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March 1982 |
p53 mutations in human cancers
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journal
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July 1991 |
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
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journal
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July 1991 |
The function of herpes simplex virus genes: a primer for genetic engineering of novel vectors.
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journal
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October 1996 |
Prevention of vertebrate neuronal death by the crmA gene
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journal
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February 1994 |
Experimental therapy of human glioma by means of a genetically engineered virus mutant
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journal
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May 1991 |
A Variant of Herpes Simplex Virus Type 2 Strain HG52 with a 1.5 kb Deletion in RL between 0 to 0.02 and 0.81 to 0.83 Map Units Is Non-neurovirulent for Mice
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journal
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March 1989 |
The Fas death factor
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journal
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March 1995 |
What is the Optimal Rodent Model for Anti-tumor Drug Testing?
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journal
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September 1998 |
Herpes simplex virus 1 RNA-binding protein US11 negatively regulates the accumulation of a truncated viral mRNA.
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journal
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January 1991 |
Transmission of Herpes-Simplex Virus type 1 in a Nursery for the Newborn Identification of Viral Isolates by D.N.A. "Fingerprinting"
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journal
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May 1978 |
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
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journal
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November 1991 |
The herpes simplex virus 1 gene for ICP34.5, which maps in inverted repeats, is conserved in several limited-passage isolates but not in strain 17syn+.
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journal
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January 1990 |
Site-specific inversion sequence of the herpes simplex virus genome: Domain and structural features
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journal
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November 1981 |
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice
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journal
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October 1978 |
Characterization of the IE110 Gene of Herpes Simplex Virus Type 1
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journal
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November 1986 |
Biological characterization of a herpes simplex virus intertypic recombinant which is completely and specifically non-neurovirulent
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journal
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November 1983 |
Status of the ICP34.5 gene in herpes simplex virus type 1 strain 17
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journal
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April 1992 |
Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of herpes simplex virus genome.
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journal
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January 1986 |
Prevention of apoptosis by a baculovirus gene during infection of insect cells
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journal
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November 1991 |
A simple method for displaying the hydropathic character of a protein
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journal
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May 1982 |
CANCER MODELS: Systems for Identifying New Drugs Are Often Faulty
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November 1997 |
Genetic Studies with Herpes Simplex Virus Type 1. The Isolation of Temperature-sensitive Mutants, their Arrangement into Complementation Groups and Recombination Analysis Leading to a Linkage Map
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journal
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March 1973 |
Location and Orientation of Homologous Sequences in the Genomes of Five Herpesviruses
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journal
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September 1983 |
Anatomy of herpes simplex virus DNA. II. Size, composition, and arrangement of inverted terminal repetitions.
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journal
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January 1975 |
Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death
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journal
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June 1991 |
The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.
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journal
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April 1992 |
Spatial and temporal control of gene therapy using ionizing radiation
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journal
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August 1995 |
A generalized technique for deletion of specific genes in large genomes: a gene 22 of herpes simplex virus 1 is not essential for growth
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journal
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July 1981 |
Inverted Repetitions in the Chromosome of Herpes Simplex Virus
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journal
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January 1974 |
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
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journal
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November 1991 |
Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus I
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journal
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January 1988 |
Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants.
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journal
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January 1978 |
An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells
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journal
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October 1996 |
Isomerization of herpes simplex virus 1 genome: identification of the cis-acting and recombination sites within the domain of the a sequence
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journal
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July 1985 |
Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients
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journal
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July 1996 |
DNA sequencing with chain-terminating inhibitors
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journal
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December 1977 |
Infections with Herpes Simplex Viruses
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journal
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March 1986 |
Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short components.
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journal
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November 1975 |
The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component.
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journal
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January 1986 |
Restitution of the UL56 gene expression of HSV-1 HFEM led to restoration of virulent phenotype; deletion of the amino acids 217 to 234 of the UL56 protein abrogates the virulent phenotype
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journal
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January 1996 |
Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer
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journal
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March 1990 |
Multipotent neural cell lines can engraft and participate in development of mouse cerebellum
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journal
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January 1992 |
Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture
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journal
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November 1990 |
Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma.
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journal
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February 1995 |
Quantitative polymerase chain reaction analysis of herpes simplex virus DNA in ganglia of mice infected with replication-incompetent mutants.
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journal
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January 1990 |
Restriction of Herpes Simplex Virus by Macrophages
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journal
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January 1971 |
Isolation of Latent Herpes Simplex Virus from the Superior Cervical and Vagus Ganglions of Human Beings
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journal
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May 1978 |
Temporal Cluster of Herpes Simplex Encephalitis: Investigation by Restriction Endonuclease Cleavage of Viral DNA
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journal
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April 1980 |
Proteins Specified by Herpes Simplex Virus XI. Identification and Relative Molar Rates of Synthesis of Structural and Nonstructural Herpes Virus Polypeptides in the Infected Cell
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journal
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January 1973 |
Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain
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journal
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August 1991 |
Genetic and biological analyses of a herpes simplex virus intertypic recombinant reduced specifically for neurovirulence.
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journal
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January 1987 |
Mechanisms and genes of cellular suicide
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journal
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March 1995 |
Comparative Sequence Analysis of the Long Repeat Regions and Adjoining Parts of the Long Unique Regions in the Genomes of Herpes Simplex Viruses Types 1 and 2
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journal
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December 1991 |
Ocular disease pattern induced by herpes simplex virus is genetically determined by a specific region of viral DNA.
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journal
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February 1982 |
Physical location of a herpes simplex virus type-1 gene function(s) specifically associated with a 10 million-fold increase in HSV neurovirulence
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journal
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November 1983 |
Gene therapy - promises, problems and prospects
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journal
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September 1997 |