Main chain acid-degradable polymers for the delivery of bioactive materials
- Oakland, CA
- Evanston, IL
- Milpitas, CA
- Cambridge, MA
Novel main chain acid degradable polymer backbones and drug delivery systems comprised of materials capable of delivering bioactive materials to cells for use as vaccines or other therapeutic agents are described. The polymers are synthesized using monomers that contain acid-degradable linkages cleavable under mild acidic conditions. The main chain of the resulting polymers readily degrade into many small molecules at low pH, but remain relatively stable and intact at physiological pH. The new materials have the common characteristic of being able to degrade by acid hydrolysis under conditions commonly found within the endosomal or lysosomal compartments of cells thereby releasing their payload within the cell. The materials can also be used for the delivery of therapeutics to the acidic regions of tumors and other sites of inflammation.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-05CH11231
- Assignee:
- U.S. Department of Energy (Washington, DC)
- Patent Number(s):
- 8,137,700
- Application Number:
- 12/299,506
- OSTI ID:
- 1039708
- Country of Publication:
- United States
- Language:
- English
Acid-Degradable Particles for Protein-Based Vaccines: Enhanced Survival Rate for Tumor-Challenged Mice Using Ovalbumin Model
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journal | November 2004 |
A Novel Strategy for Encapsulation and Release of Proteins: Hydrogels and Microgels with Acid-Labile Acetal Cross-Linkers
|
journal | October 2002 |
Enhanced antigen presentation and immunostimulation of dendritic cells using acid-degradable cationic nanoparticles
|
journal | July 2005 |
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