Synthetic peptides that cause F-actin bundling and block actin depolymerization
- Raleigh, NC
- Savoy, IL
- Berkeley, CA
Synthetic peptides derived from sucrose synthase, and having homology to actin and actin-related proteins, sharing a common motif, useful for causing acting bundling and preventing actin depolymerization. Peptides exhibiting the common motif are described, as well as specific synthetic peptides which caused bundled actin and inhibit actin depolymerization. These peptides can be useful for treating a subject suffering from a disease characterized by cells having neoplastic growth, for anti-cancer therapeutics, delivered to subjects solely, or concomitantly or sequentially with other known cancer therapeutics. These peptides can also be used for stabilizing microfilaments in living cells and inhibiting growth of cells.
- Research Organization:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC03-76SF00098; AI01-91ER20031
- Assignee:
- The Regents of the University of California (Oakland, CA); North Carolina State University (Raleigh, NC); The Regents of the University of California (Oakland, CA)
- Patent Number(s):
- 8,039,438
- Application Number:
- 10/576,757
- OSTI ID:
- 1028779
- Country of Publication:
- United States
- Language:
- English
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