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Title: Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI

Abstract

An integral microfluidic device includes an alkali vapor cell and microfluidic channel, which can be used to detect magnetism for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Small magnetic fields in the vicinity of the vapor cell can be measured by optically polarizing and probing the spin precession in the small magnetic field. This can then be used to detect the magnetic field of in encoded analyte in the adjacent microfluidic channel. The magnetism in the microfluidic channel can be modulated by applying an appropriate series of radio or audio frequency pulses upstream from the microfluidic chip (the remote detection modality) to yield a sensitive means of detecting NMR and MRI.

Inventors:
 [1];  [2];  [3];  [4];  [5];  [5];  [6];  [7];  [6]
  1. Oakland, CA
  2. Los Alamos, NM
  3. El Cerrito, CA
  4. Plainsboro, NJ
  5. Boulder, CO
  6. Berkeley, CA
  7. Houston, TX
Publication Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1025887
Patent Number(s):
7,994,783
Application Number:
12/367,292
Assignee:
The Regents of the Univerisity of California (Oakland, CA)
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Citation Formats

Ledbetter, Micah P, Savukov, Igor M, Budker, Dmitry, Shah, Vishal K, Knappe, Svenja, Kitching, John, Michalak, David J, Xu, Shoujun, and Pines, Alexander. Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI. United States: N. p., 2011. Web.
Ledbetter, Micah P, Savukov, Igor M, Budker, Dmitry, Shah, Vishal K, Knappe, Svenja, Kitching, John, Michalak, David J, Xu, Shoujun, & Pines, Alexander. Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI. United States.
Ledbetter, Micah P, Savukov, Igor M, Budker, Dmitry, Shah, Vishal K, Knappe, Svenja, Kitching, John, Michalak, David J, Xu, Shoujun, and Pines, Alexander. 2011. "Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI". United States. https://www.osti.gov/servlets/purl/1025887.
@article{osti_1025887,
title = {Integrated microchip incorporating atomic magnetometer and microfluidic channel for NMR and MRI},
author = {Ledbetter, Micah P and Savukov, Igor M and Budker, Dmitry and Shah, Vishal K and Knappe, Svenja and Kitching, John and Michalak, David J and Xu, Shoujun and Pines, Alexander},
abstractNote = {An integral microfluidic device includes an alkali vapor cell and microfluidic channel, which can be used to detect magnetism for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Small magnetic fields in the vicinity of the vapor cell can be measured by optically polarizing and probing the spin precession in the small magnetic field. This can then be used to detect the magnetic field of in encoded analyte in the adjacent microfluidic channel. The magnetism in the microfluidic channel can be modulated by applying an appropriate series of radio or audio frequency pulses upstream from the microfluidic chip (the remote detection modality) to yield a sensitive means of detecting NMR and MRI.},
doi = {},
url = {https://www.osti.gov/biblio/1025887}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 09 00:00:00 EDT 2011},
month = {Tue Aug 09 00:00:00 EDT 2011}
}

Works referenced in this record:

Subpicotesla atomic magnetometry with a microfabricated vapour cell
journal, November 2007


Dispersion measurements using time-of-flight remote detection MRI
journal, May 2007


Time-of-Flight Flow Imaging of Two-Component Flow inside a Microfluidic Chip
journal, January 2007


Chip-scale atomic magnetometer
journal, December 2004


A subfemtotesla multichannel atomic magnetometer
journal, April 2003


Zero-field remote detection of NMR with a microfabricated atomic magnetometer
journal, February 2008


Magnetic resonance imaging with an optical atomic magnetometer
journal, August 2006


Amplification of xenon NMR and MRI by remote detection
journal, July 2003