Coordination chemistry of the {sup 212}Pb/{sup 212}Bi nuclear transformation: Alpha-emitting radiopharmaceuticals. Final technical report

Technical Report · Wed Jul 01 00:00:00 EDT 1992

DOI:https://doi.org/10.2172/10168019· OSTI ID:10168019

Parks, N J; Harris, W R; Keen, C L; Cooper, S R

Subdivisions of this project are: (a) the synthesis of prototypical thiolate and dithiocarbamate based hexacoordinate complexes, (b) radiochemical engineering for generation of no-carrier-added lead and bismuth radioelements, (c) the first isolation of bismuth-binding proteins from in vivo studies with cyclotron produced {sup 205/206}Bi tracer, and (d) initial development of transport mechanisms for the intracellular radiobiological study of alpha emitting bismuth, and (e) the initiation of chemical equilibrium studies and biochemical pathways with cyclotron-produced, no-carrier-added, {sup 203}Pb (T{sub 1/2} = 51 hr).

• Research Organization: California Univ., Davis, CA (United States). Lab. for Energy-Related Health Research
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG03-90ER61035
• OSTI ID: 10168019
• Report Number(s): DOE/ER/61035-T1; UCD-472-504; ON: DE92019048
• Resource Relation: Other Information: PBD: Jul 1992
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
RADIOISOTOPE GENERATORS
DESIGN
PROGRESS REPORT
CHELATING AGENTS
DITHIOLS
PH VALUE
LEAD 212
BISMUTH 212
CARRIER-FREE ISOTOPES
RADIOPHARMACEUTICALS
ALPHA DECAY RADIOISOTOPES
LIQUID COLUMN CHROMATOGRAPHY
BISMUTH COMPLEXES
PROTEINS
TRACER TECHNIQUES
ANIMAL TISSUES
RADIOBIOLOGY
LEAD 203
400703
551001
RADIOISOTOPE PRODUCTION