Flow method and apparatus for screening chemicals using micro x-ray fluorescence

Patent · Tue Apr 26 00:00:00 EDT 2011

OSTI ID:1016687

Warner, Benjamin P ^[1]; Havrilla, George J ^[1]; Miller, Thomasin C ^[2]; Lewis, Cris ^[1]; Mahan, Cynthia A ^[1]; Wells, Cyndi A ^[1]

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1. Los Alamos, NM
2. Bartlesville, OK

Method and apparatus for screening chemicals using micro x-ray fluorescence. A method for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder involves flow separating a solution of chemicals and target binders into separated components, exposing them to an x-ray excitation beam, detecting x-ray fluorescence signals from the components, and determining from the signals whether or not a binding event between a chemical and target binder has occurred.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: W-7405-ENG- 36
• Assignee: Los Alamos National Security, LLC (Los Alamos, NM)
• Patent Number(s): 7,929,662
• Application Number: US Patent Application 12/396,592
• OSTI ID: 1016687
• Country of Publication: United States
• Language: English

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