The role of constitutive and inducible processes in the response of human squamous cell carcinoma cell lines to ionizing radiation

Conference · Tue Jun 01 00:00:00 EDT 1993

OSTI ID:10162070

Schwartz, J L

The inherent radiation sensitivity of the cells within a tumor is thought to contribute to the success or failure of radiation therapy. In vitro studies have shown that radiation sensitivity differences in squamous cell carcinoma cell lines reflect alterations in DNA repair. These alterations result from constitutive changes in chromosome organization, not radiation-inducible processes. While inducible responses may play some role in the radiation response of tumor cells, there is no evidence for their involvement in inherent tumor cell radiosensitivity differences or in the success or failure of radiotherapy for squamous cell carcinomas.

• Research Organization: Argonne National Lab., IL (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 10162070
• Report Number(s): ANL/BIM/CP-79672; CONF-9305202-2; ON: DE93015150
• Resource Relation: Conference: Molecular, cellular, and genetic basis of radiosensitivity at low doses: a case of induced repair,Whistler (Canada),9-13 May 1993; Other Information: PBD: [1993]
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SOMATIC CELLS
BIOLOGICAL RADIATION EFFECTS
MAN
DNA REPAIR
ONCOGENIC TRANSFORMATIONS
ENZYME INDUCTION
RADIOTHERAPY
X RADIATION
SURVIVAL CURVES
CELL CYCLE
560120
560151
RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE