U.S. Department of EnergyOffice of Scientific and Technical Information
Ames test mutagenicity studies of the subfractions of the mild gasification composite material, MG-120. [Quarterly report, January--March 1992]
Abstract
Mutagenicity of six mild gasification product samples was studied using the Ames Salmonella/microsomal assay system. The results of the Ames testing of the MG-119 and MG-120 subfractions indicate significant mutagenic activity only in the nonpolar neutral fraction. The activity was evident on bacterial strains, TA98 and TA100, with and without metabolic activation for MG-120, and with metabolic activation for MG-119. Previous testing of MG-119 and MG-120 when solvated in DMSO had shown possible, but unconfirmable, mutagenic activity. Tween 80-solvated MG-119 and MG-120 showed low, but significant, mutagenic activity only on TA98 with metabolic activation. Comparison of these results indicate an inhibition of the mutagenic components by nonmutagenic components in the complex mixture. 4 refs., 2 tabs.
- Publication Date:
- Research Org.:
- National Inst. for Occupational Safety and Health, Morgantown, WV (United States). Div. of Respiratory Disease Studies
- Sponsoring Org.:
- USDOE, Washington, DC (United States)
- OSTI Identifier:
- 10161893
- Report Number(s):
- DOE/MC/26018-T15
ON: DE92017653
- DOE Contract Number:
- AI21-89MC26018
- Resource Type:
- Technical Report
- Resource Relation:
- Other Information: PBD: 17 Apr 1992
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 01 COAL, LIGNITE, AND PEAT; COAL GASIFICATION; CONDENSATES; COAL LIQUIDS; TOXICITY; MUTAGEN SCREENING; PROGRESS REPORT; EXPERIMENTAL DATA; SALMONELLA; 560300; 016000; 010404; CHEMICALS METABOLISM AND TOXICOLOGY; HEALTH AND SAFETY; GASIFICATION
Citation Formats
. Ames test mutagenicity studies of the subfractions of the mild gasification composite material, MG-120. [Quarterly report, January--March 1992]. United States: N. p., 1992.
Web. doi:10.2172/10161893.
. Ames test mutagenicity studies of the subfractions of the mild gasification composite material, MG-120. [Quarterly report, January--March 1992]. United States. https://doi.org/10.2172/10161893
. 1992.
"Ames test mutagenicity studies of the subfractions of the mild gasification composite material, MG-120. [Quarterly report, January--March 1992]". United States. https://doi.org/10.2172/10161893. https://www.osti.gov/servlets/purl/10161893.
@article{osti_10161893,
title = {Ames test mutagenicity studies of the subfractions of the mild gasification composite material, MG-120. [Quarterly report, January--March 1992]},
author = {},
abstractNote = {Mutagenicity of six mild gasification product samples was studied using the Ames Salmonella/microsomal assay system. The results of the Ames testing of the MG-119 and MG-120 subfractions indicate significant mutagenic activity only in the nonpolar neutral fraction. The activity was evident on bacterial strains, TA98 and TA100, with and without metabolic activation for MG-120, and with metabolic activation for MG-119. Previous testing of MG-119 and MG-120 when solvated in DMSO had shown possible, but unconfirmable, mutagenic activity. Tween 80-solvated MG-119 and MG-120 showed low, but significant, mutagenic activity only on TA98 with metabolic activation. Comparison of these results indicate an inhibition of the mutagenic components by nonmutagenic components in the complex mixture. 4 refs., 2 tabs.},
doi = {10.2172/10161893},
url = {https://www.osti.gov/biblio/10161893},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Apr 17 00:00:00 EDT 1992},
month = {Fri Apr 17 00:00:00 EDT 1992}
}