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Title: Radial arrays of nano-electrospray ionization emitters and methods of forming electrosprays

Patent ·
OSTI ID:1016125

Electrospray ionization emitter arrays, as well as methods for forming electrosprays, are described. The arrays are characterized by a radial configuration of three or more nano-electrospray ionization emitters without an extractor electrode. The methods are characterized by distributing fluid flow of the liquid sample among three or more nano-electrospray ionization emitters, forming an electrospray at outlets of the emitters without utilizing an extractor electrode, and directing the electrosprays into an entrance to a mass spectrometry device. Each of the nano-electrospray ionization emitters can have a discrete channel for fluid flow. The nano-electrospray ionization emitters are circularly arranged such that each is shielded substantially equally from an electrospray-inducing electric field.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
7,816,645
Application Number:
12/046,207
OSTI ID:
1016125
Country of Publication:
United States
Language:
English

References (7)

Porous Polymer Monolith Assisted Electrospray journal November 2004
Effects of capillary spacing on EHD spraying from an array of cone jets journal November 2002
Increase of electrospray throughput using multiplexed microfabricated sources for the scalable generation of monodisperse droplets journal June 2006
Nanoelectrospray mass spectrometry using non-metalized, tapered (50 → 10 μm) fused-silica capillaries journal April 1998
Electrospray and Taylor-Cone theory, Dole's beam of macromolecules at last? journal September 1994
Influence of space charge on the scale-up of multiplexed electrosprays journal October 2007
Stabilization of monodisperse electrosprays in the multi-jet mode via electric field enhancement journal March 2006

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