Synthesis and evaluation of boron compounds for neutron capture therapy of malignant brain tumors. Technical progress report No. 1, May 1, 1990--January 31, 1991

Technical Report · Mon Dec 31 00:00:00 EST 1990

DOI:https://doi.org/10.2172/10159681· OSTI ID:10159681

Soloway, A H; Barth, R F

Boron neutron capture therapy offers the potentiality for treating brain tumors currently resistant to treatment. The success of this form of therapy is directly dependent upon the delivery of sufficient numbers of thermal-neutrons to tumor cells which possess high concentrations of B-10. The objective of this project is to develop chemical methodology to synthesize boron-containing compounds with the potential for becoming incorporated into rapidly-dividing malignant brain tumor cells and excluded from normal components of the brain and surrounding tissues, to develope biological methods for assessing the potential of the compound by use of cell culture or intratumoral injection, to develop analytical methodology for measuring boron in cells and tissue using direct current plasma atomic emission spectroscopy (DCP-AES) and alpha track autoradiography, to develop biochemical and HPLC procedures for evaluating compound uptake and tissue half-life, and to develop procedures required to assess both in vitro and vivo efficacy of BNCT with selected compounds.

• Research Organization: Ohio State Univ. Research Foundation, Columbus, OH (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-90ER60972
• OSTI ID: 10159681
• Report Number(s): DOE/ER/60972-3; ON: DE93015880
• Resource Relation: Other Information: PBD: [1990]
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
GLIOMAS
NEUTRON THERAPY
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
NUCLEOSIDES
LABELLING
PROGRESS REPORT
BORON COMPOUNDS
URIDINE
RATS
EXPERIMENTAL NEOPLASMS
CELL CULTURES
550603
400202
EXTERNAL RADIATION IN THERAPY
ISOTOPE EFFECTS, ISOTOPE EXCHANGE, AND ISOTOPE SEPARATION