Use of bioassays in assessing health hazards from complex mixtures: A RASH analysis

Conference · Thu Oct 14 00:00:00 EDT 1993

OSTI ID:10155830

Jones, T D

The Finney harmonic mean model for joint toxicity of ingredients in mixtures can be used to estimate the toxicity of the neat compound if one component can be substituted in potency-adjusted-doses for each of the other components. Chemical analysis data and relative potency values (computed according to the Rapid Screening of Hazard (RASH) method) were used to compare the toxicities as predicted from ingredients of cigarette smoke, PAHs in diesel exhaust, asphalt, coal tar, pitch, and creosote with the measured toxicities of the neat mixtures. Accuracy for cigarette smoke condensate, coal tar, pitch, and creosote were within a factor of three; asphalt within a factor of 18; but the PAC content of diesel particulate was inadequate to accurately describe the toxicity of diesel emissions.

• Research Organization: Oak Ridge National Lab., TN (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 10155830
• Report Number(s): CONF-940301-35; ON: DE94012733
• Resource Relation: Conference: 207. spring national meeting of the American Chemical Society (ACS),San Diego, CA (United States),13-18 Mar 1994; Other Information: PBD: 14 Oct 1993
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
TOBACCO SMOKES
TOXICITY
POLYCYCLIC AROMATIC HYDROCARBONS
COAL TAR
CREOSOTE
HEALTH HAZARDS
RISK ASSESSMENT
DIESEL FUELS
CHEMICAL ANALYSIS
BIOASSAY
EQUATIONS
560300
990200
CHEMICALS METABOLISM AND TOXICOLOGY
MATHEMATICS AND COMPUTERS