Tumorigenesis in the U.S. radium luminizers: How unsafe was this occupation?

Thomas, R G

Title: Tumorigenesis in the U.S. radium luminizers: How unsafe was this occupation?

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Abstract

Dose-response data are presented from the U.S. female workers who were exposed to radium through the painting of luminous dials and who subsequently had their skeletal burdens measured by whole-body counting and radon breath analyses. Lognormal data analyses were done for radium-induced bone sarcomas and head carcinomas after the populations of the respective doses were first determined to be lognormally distributed. The calculated geometric mean and standard deviation for each dose population were used to construct lognormal distributions that subsequently could be used for intercomparisons. To date, a total of 1,391 female luminizers with average estimated skeletal doses below 10 Gy have not shown bone sarcomas or head carcinomas. A primary purpose of this paper is to support the case that {sup 226.228}Ra is one of the radionuclide sources that exemplify in humans a {open_quote}threshold{close_quotes} dose or a dose below which there should be little concern for tumorigenesis.

Authors:: Thomas, R G

Publication Date:: Sun May 01 00:00:00 EDT 1994

Research Org.:: Argonne National Lab., IL (United States)

Sponsoring Org.:: USDOE, Washington, DC (United States)

OSTI Identifier:: 10144511

Report Number(s):: ANL/ER/CP-81045; CONF-940437-3
ON: DE94010444; TRN: 94:005074

DOE Contract Number:: W-31109-ENG-38

Resource Type:: Conference

Resource Relation:: Conference: International seminar on health effects of radium and thorium,Heidelberg (Germany),18-22 Apr 1994; Other Information: PBD: [1994]

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; HEAD; CARCINOMAS; RADIUM; DOSE-RESPONSE RELATIONSHIPS; OCCUPATIONAL EXPOSURE; DIAL PAINTERS; BIOLOGICAL RADIATION EFFECTS; SKELETON; SARCOMAS; RADIATION DOSES; RADON; WHOLE-BODY COUNTING; WOMEN; 560151; 550900; MAN; PATHOLOGY

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                    Thomas, R G. Tumorigenesis in the U.S. radium luminizers: How unsafe was this occupation?.  United States: N. p., 1994. 
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                    Thomas, R G. Tumorigenesis in the U.S. radium luminizers: How unsafe was this occupation?.  United States.

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                    Thomas, R G. 1994.  
        "Tumorigenesis in the U.S. radium luminizers: How unsafe was this occupation?".  United States.  https://www.osti.gov/servlets/purl/10144511.

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@article{osti_10144511,

  title        = {Tumorigenesis in the U.S. radium luminizers: How unsafe was this occupation?},

  author       = {Thomas, R G},

  abstractNote = {Dose-response data are presented from the U.S. female workers who were exposed to radium through the painting of luminous dials and who subsequently had their skeletal burdens measured by whole-body counting and radon breath analyses. Lognormal data analyses were done for radium-induced bone sarcomas and head carcinomas after the populations of the respective doses were first determined to be lognormally distributed. The calculated geometric mean and standard deviation for each dose population were used to construct lognormal distributions that subsequently could be used for intercomparisons. To date, a total of 1,391 female luminizers with average estimated skeletal doses below 10 Gy have not shown bone sarcomas or head carcinomas. A primary purpose of this paper is to support the case that {sup 226.228}Ra is one of the radionuclide sources that exemplify in humans a {open_quote}threshold{close_quotes} dose or a dose below which there should be little concern for tumorigenesis.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/10144511},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Sun May 01 00:00:00 EDT 1994},

  month        = {Sun May 01 00:00:00 EDT 1994}

}

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