Synthesis and in-vivo detection of boronated compounds for use in BNCT. Comprehensive progress report, August 1, 1989--July 31, 1992
The primary objective of the DOE program at The University of Tennessee Graduate School of Medicine is the development of effective molecular medicine for use in neutron-capture therapy (NCT). The research focuses primarily on the preparation of new boron-rich NCT agents and the technology to detect them in-vivo. The detection technology involves the development of effective magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques for verifying and measuring NCT agents in-vivo. The synthetic program is directed toward the design of novel boron NCT (BNCT) agents which are targeted to the cell nucleus and gadolinium liposomes targeted to the liver. The UT-DOE program is unique in that it has access to both state-of-the-art whole-body and microscopy MRI instruments.
- Research Organization:
- University of Tennessee Medical Center, Knoxville, TN (United States). Dept. of Radiology
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG05-89ER60892
- OSTI ID:
- 10143742
- Report Number(s):
- DOE/ER/60892-3; ON: DE92013583
- Resource Relation:
- Other Information: PBD: Jan 1992
- Country of Publication:
- United States
- Language:
- English
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Synthesis and in-vivo detection of boronated compounds for use in BNCT
Synthesis and in-vivo detection of boronated compounds for use in BNCT
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38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
LIPOSOMES
LABELLING
CARBORANES
CHEMICAL PREPARATION
BORON 11
MAGNETIC RESONANCE
PROGRESS REPORT
NEUTRON CAPTURE THERAPY
GADOLINIUM COMPOUNDS
AMINO ACIDS
ORGANOMETALLIC COMPOUNDS
RELAXATION TIME
550604
400702
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UNSEALED RADIONUCLIDES IN THERAPY
PROPERTIES OF RADIOACTIVE MATERIALS
EXTERNAL RADIATION IN DIAGNOSTICS