U.S. Department of EnergyOffice of Scientific and Technical Information
Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof
Abstract
The present invention provides methods and compositions for the diagnosis and treatment of cells lacking normal growth arresting characteristic. The present invention demonstrates that many tumor cells lack normal cell surface .alpha.-dystroglycan and thereby lack dystroglycan function. Dystroglycan can be lost from the cell surface by proteolytic shedding of a fragment of .alpha.-dystroglycan into the surrounding medium. Upon restoration of dystroglycan function and over-expression of the dystroglycan gene, the once tumorigenic cells revert to non-tumorigenic cells which polarize and arrest cell growth in the presence of basement membrane proteins, demonstrating that dystroglycan functions as a tumor marker and suppressor.
- Inventors:
-
- Berkeley, CA
- Albany, CA
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1014177
- Patent Number(s):
- 7,666,850
- Application Number:
- US Patent Application 11/150,406
- Assignee:
- The Regents of the University of California (Oakland, CA)
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Bissell, Mina J, and Muschler, John L. Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof. United States: N. p., 2010.
Web.
Bissell, Mina J, & Muschler, John L. Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof. United States.
Bissell, Mina J, and Muschler, John L. 2010.
"Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof". United States. https://www.osti.gov/servlets/purl/1014177.
@article{osti_1014177,
title = {Drug screens based on the newly found role of dystroglycan proteolysis and restoration of dystroglycan function thereof},
author = {Bissell, Mina J and Muschler, John L},
abstractNote = {The present invention provides methods and compositions for the diagnosis and treatment of cells lacking normal growth arresting characteristic. The present invention demonstrates that many tumor cells lack normal cell surface .alpha.-dystroglycan and thereby lack dystroglycan function. Dystroglycan can be lost from the cell surface by proteolytic shedding of a fragment of .alpha.-dystroglycan into the surrounding medium. Upon restoration of dystroglycan function and over-expression of the dystroglycan gene, the once tumorigenic cells revert to non-tumorigenic cells which polarize and arrest cell growth in the presence of basement membrane proteins, demonstrating that dystroglycan functions as a tumor marker and suppressor.},
doi = {},
url = {https://www.osti.gov/biblio/1014177},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 23 00:00:00 EST 2010},
month = {Tue Feb 23 00:00:00 EST 2010}
}
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Works referenced in this record:
A Role for Dystroglycan in Basement Membrane Assembly
journal, December 1998
- Henry, Michael D.; Campbell, Kevin P.
- Cell, Vol. 95, Issue 6
Functional Rescue of the Sarcoglycan Complex in the BIO 14.6 Hamster Using δ-Sarcoglycan Gene Transfer
journal, May 1998
- Holt, Kathleen H.; Lim, Leland E.; Straub, Volker
- Molecular Cell, Vol. 1, Issue 6
Value of Prostate-Specific
Antigen as a Tumor Marker
journal, January 1993
- Wirth, M.; Manseck, A.; Heimbach, D.
- European Urology, Vol. 24, Issue 2
Non-muscle alpha-dystroglycan is involved in epithelial development.
journal, July 1995
- Durbeej, M.; Larsson, E.; Ibraghimov-Beskrovnaya, O.
- The Journal of Cell Biology, Vol. 130, Issue 1
Another Anniversary for the War on Cancer
journal, March 1994
- Dermer, Gerald B.
- Bio/Technology, Vol. 12, Issue 3
Reduced expression of dystroglycan in breast and prostate cancer
journal, August 2001
- Henry, Michael D.; Cohen, Michael B.; Campbell, Kevin P.
- Human Pathology, Vol. 32, Issue 8