Selection and manipulation of immunoglobulins for radionuclide delivery

Technical Report · Thu Dec 31 00:00:00 EST 1992

DOI:https://doi.org/10.2172/10139566· OSTI ID:10139566

Steplewski, Z; Curtis, P ^[1]; Hainfeld, J; Mausner, L; Mease, R; Srivastava, S ^[2]

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1. The Wistar Institute, Philadelphia, PA (United States)
2. Brookhaven National Lab., Upton, NY (United States)

This report describes a collection of monoclonal antibodies that are candidates for use in radioimmunotherapy towards neoplasms of the gastrointestinal tract, breast, or of astrocytomas. In addition a large series of candidate radionuclides to conjugate to antibodies for therapeutic uses are discussed with respect to potential therapeutic utility and to means of radionuclide production.

• Research Organization: Brookhaven National Lab. (BNL), Upton, NY (United States)
• Sponsoring Organization: Department of Health and Human Services, Washington, DC (United States)
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 10139566
• Report Number(s): BNL-60153; ON: DE94009043; CNN: Grant CA10815; Grant CA21124; Grant CA51958
• Resource Relation: Other Information: PBD: [1992]
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
IMMUNOGLOBULINS
LABELLING
RADIOIMMUNOTHERAPY
IODINE 125
OLIGOSACCHARIDES
GLYCOPROTEINS
GROWTH FACTORS
COPPER 67
SAMARIUM 153
RHODIUM 105
SCANDIUM 47
GOLD 199
IODINE 131
YTTRIUM 90
INDIUM 111
RHENIUM 186
LUTETIUM 177
IRIDIUM 194
RHENIUM 188
DTPA
RADIOISOTOPE GENERATORS
550604
400703
UNSEALED RADIONUCLIDES IN THERAPY
RADIOISOTOPE PRODUCTION