Problems in mechanistic theoretical models for cell transformation by ionizing radiation

Conference · Tue Oct 01 00:00:00 EDT 1991

OSTI ID:10135467

Chatterjee, A; Holley, W R

A mechanistic model based on yields of double strand breaks has been developed to determine the dose response curves for cell transformation frequencies. At its present stage the model is applicable to immortal cell lines and to various qualities (X-rays, Neon and Iron) of ionizing radiation. Presently, we have considered four types of processes which can lead to activation phenomena: (1) point mutation events on a regulatory segment of selected oncogenes, (2) inactivation of suppressor genes, through point mutation, (3) deletion of a suppressor gene by a single track, and (4) deletion of a suppressor gene by two tracks.

• Research Organization: Lawrence Berkeley Lab., CA (United States)
• Sponsoring Organization: USDOE, Washington, DC (United States)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 10135467
• Report Number(s): LBL-31398; CONF-9109107-5; ON: DE92010265
• Resource Relation: Conference: Workshop on biophysical modelling of radiation effects,Padua (Italy),2-5 Sep 1991; Other Information: PBD: Oct 1991
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
CARCINOGENESIS
MOLECULAR BIOLOGY
MUTAGENESIS
DNA
BIOLOGICAL RADIATION EFFECTS
IONIZING RADIATIONS
STRAND BREAKS
MUTATIONS
MATHEMATICAL MODELS
560120
990200
RADIATION EFFECTS ON BIOCHEMICALS, CELLS, AND TISSUE CULTURE
MATHEMATICS AND COMPUTERS