The mechanism of switching from an acidogenic to butanol-acetone fermentation by Clostridium acetobutylicum. Technical progress report, July 1990--December 1992
The overall objective of this project is to elucidate the detailed mechanism by which solvent-forming bacteria such as Clostridium acetobutylicum regulate the well-known shift in fermentation pathway between alcohol-acetone and organic acid production. It is desired to eventually isolate and describe: (1) the regulatory genes and protein elements that determine induction of synthesis of the solvent-pathway enzymes; and (2) how this regulation system interacts with the sporulatin induction and development program and with related pathways such as granulse and exopolysaccharide formation in clostridia. A working model forhow clostridial control systems work can be derived from recent research on stress systems in E. coli and sporulation in Bacillus subtilis.
- Research Organization:
- Minnesota Univ., Minneapolis, MN (United States). Medical School
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-86ER13512
- OSTI ID:
- 10128398
- Report Number(s):
- DOE/ER/13512-T2; ON: DE93008396
- Resource Relation:
- Other Information: PBD: 1992
- Country of Publication:
- United States
- Language:
- English
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The mechanism of switching from an acidogenic to butanol-acetone fermentation by Clostridium acetobutylicum
The mechanism of switching from an acidogenic to butanol-acetone fermentation by Clostridium acetobutylicum