Development of more efficacious Tc-99m organ imaging agents for use in nuclear medicine by analytical characterization of radiopharmaceutical mixtures. Progress report, September 1, 1989--January 31, 1992
The long-range objective of this research program is the development of more efficacious technetium-99m radiopharmaceuticals for use as imaging agents in diagnostic nuclear medicine. We seek to isolate and develop distinct site imaging agents, each of which has properties optimized to provide diagnostic information concerning a given pathological condition. The specific objectives during the period (9/1/89 to 8/31/92) include: (1) Development of strategies for improving yields of specific Tc-diphosphonate complexes with optimum imaging properties; (2) Development of electrodes for rapid in situ electrochemical generation of skeletal imaging agents; (3) Development of electrochemical sensors for {Tc} and Re imaging agents; (4) Characterization of stable {Tc}- and Re-diphosphonate complexes obtainable in high yield by structural studies with techniques such as NMR, EXAFS, and Raman spectroscopy; (5) Development of improved separation techniques for the characterization of diphosphonate skeletal imaging agents; (6) Evaluation of the effect of the biological milieu on {Tc}-diphosphonate complexes; and (7) Electrochemical studies of technetium and rhenium complexes synthesized by Professor Deutsch`s research group for heart and brain imaging.
- Research Organization:
- Cincinnati Univ., OH (United States). Dept. of Chemistry
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- FG02-86ER60487
- OSTI ID:
- 10127701
- Report Number(s):
- DOE/ER/60487-6; ON: DE92008800
- Resource Relation:
- Other Information: PBD: 24 Jan 1992
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
PHOSPHONATES
CHEMICAL PREPARATION
TECHNETIUM COMPLEXES
PROGRESS REPORT
RADIOPHARMACEUTICALS
TECHNETIUM 99
ELECTROCHEMISTRY
REDUCTION
ELECTROPHORESIS
BIOCHEMISTRY
550601
400703
UNSEALED RADIONUCLIDES IN DIAGNOSTICS
RADIOISOTOPE PRODUCTION