Urine sample collection protocols for bioassay samples
Abstract
In vitro radiobioassay analyses are used to measure the amount of radioactive material excreted by personnel exposed to the potential intake of radioactive material. The analytical results are then used with various metabolic models to estimate the amount of radioactive material in the subject`s body and the original intake of radioactive material. Proper application of these metabolic models requires knowledge of the excretion period. It is normal practice to design the bioassay program based on a 24-hour excretion sample. The Hanford bioassay program simulates a total 24-hour urine excretion sample with urine collection periods lasting from one-half hour before retiring to one-half hour after rising on two consecutive days. Urine passed during the specified periods is collected in three 1-L bottles. Because the daily excretion volume given in Publication 23 of the International Commission on Radiological Protection (ICRP 1975, p. 354) for Reference Man is 1.4 L, it was proposed to use only two 1-L bottles as a cost-saving measure. This raised the broader question of what should be the design capacity of a 24-hour urine sample kit.
- Authors:
- Publication Date:
- Research Org.:
- Pacific Northwest Lab., Richland, WA (United States)
- Sponsoring Org.:
- USDOE, Washington, DC (United States)
- OSTI Identifier:
- 10114414
- Report Number(s):
- PNL-SA-21397; CONF-9211116-8
ON: DE93004838
- DOE Contract Number:
- AC06-76RL01830
- Resource Type:
- Conference
- Resource Relation:
- Conference: 38. annual conference on bioassay, analytical and environmental radiochemistry,Santa Fe, NM (United States),2-6 Nov 1992; Other Information: PBD: Nov 1992
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS; 61 RADIATION PROTECTION AND DOSIMETRY; URINE; RADIOASSAY; BIOASSAY; QUALITATIVE CHEMICAL ANALYSIS; PERSONNEL; TRITIUM; VOLUME; STATISTICS; DOSIMETRY; 054000; 560101; HEALTH AND SAFETY; DOSIMETRY AND MONITORING
Citation Formats
MacLellan, J A, and McFadden, K M. Urine sample collection protocols for bioassay samples. United States: N. p., 1992.
Web.
MacLellan, J A, & McFadden, K M. Urine sample collection protocols for bioassay samples. United States.
MacLellan, J A, and McFadden, K M. 1992.
"Urine sample collection protocols for bioassay samples". United States. https://www.osti.gov/servlets/purl/10114414.
@article{osti_10114414,
title = {Urine sample collection protocols for bioassay samples},
author = {MacLellan, J A and McFadden, K M},
abstractNote = {In vitro radiobioassay analyses are used to measure the amount of radioactive material excreted by personnel exposed to the potential intake of radioactive material. The analytical results are then used with various metabolic models to estimate the amount of radioactive material in the subject`s body and the original intake of radioactive material. Proper application of these metabolic models requires knowledge of the excretion period. It is normal practice to design the bioassay program based on a 24-hour excretion sample. The Hanford bioassay program simulates a total 24-hour urine excretion sample with urine collection periods lasting from one-half hour before retiring to one-half hour after rising on two consecutive days. Urine passed during the specified periods is collected in three 1-L bottles. Because the daily excretion volume given in Publication 23 of the International Commission on Radiological Protection (ICRP 1975, p. 354) for Reference Man is 1.4 L, it was proposed to use only two 1-L bottles as a cost-saving measure. This raised the broader question of what should be the design capacity of a 24-hour urine sample kit.},
doi = {},
url = {https://www.osti.gov/biblio/10114414},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Nov 01 00:00:00 EST 1992},
month = {Sun Nov 01 00:00:00 EST 1992}
}