Apparatus for detecting and recognizing analytes based on their crystallization patterns

Patent · Tue Dec 14 00:00:00 EST 2010

OSTI ID:1011387

Morozov, Victor ^[1]; Bailey, Charles L ^[2]; Vsevolodov, Nikolai N ^[3]; Elliott, Adam ^[1]

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1. Manassas, VA
2. Cross Junction, VA
3. Kensington, MD

The invention contemplates apparatuses for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as "crystallization patterns") containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. Changes in the crystallization patterns of a number of amino-acids can be used as a "signature" of a protein added. Also, changes in the crystallization patterns, as well as the character of such changes, can be used as recognition elements in analysis of protein molecules.

• Research Organization: George Mason Intellectual Properties, Inc. (Fairfax, VA)
• Sponsoring Organization: USDOE
• DOE Contract Number: FC52-04NA25455
• Assignee: George Mason Intellectual Properties, Inc. (Fairfax, VA)
• Patent Number(s): 7,850,915
• Application Number: 12/041,295
• OSTI ID: 1011387
• Country of Publication: United States
• Language: English