Species differences in metabolism of 1,3-butadiene
1,3-Butadiene (BD) is a 4-carbon gaseous compound with two double bonds. Used in high tonnage to make styrene-butadiene polymers in the rubber industry. Because of large amounts in use, BD was tested for toxicity in 2-year inhalation exposures of both Sprague-Dawley rats and B6C3F{sub 1} mice. The results of the two-species studies were dramatically different. In the initial study in mice, BD was shown to be a potent multiple-site carcinogen at exposure levels of 625 and 1250 ppM. There were increased incidences of neoplasia in the heart, lung, mammary gland, and ovary; malignant lymphomas resulted in early deaths of the mice so that the planned 2-year study was stopped after only 61 weeks of exposure. The second study in mice was conducted at much lower exposure concentrations (6.25, 20, 62.5, 200, and 625 ppM) and lasted 104 weeks. Increased incidences of hemangiosarcomas of the heart and lung neoplasia were observed in males exposed to 62.5 ppM BD, while females had increased lung neoplasia even at the 6.25 ppM exposure level. Early deaths from lymphomas were again observed at the high exposure concentration (625 ppm). A noncancer toxicity observed in mice was a macrocytic, megaloblastic anemia.
- Research Organization:
- Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC04-76EV01013
- OSTI ID:
- 10112068
- Report Number(s):
- CONF-950156-1; ON: DE95006163
- Resource Relation:
- Conference: 5. international symposium on biological intermediates,Munich (Germany),3-5 Jan 1995; Other Information: PBD: [1995]
- Country of Publication:
- United States
- Language:
- English
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