Gene Expression in the Third Dimension: The ECM-nucleus Connection

Journal Article · Thu Oct 01 00:00:00 EDT 2009 · Journal Mammary Gland Biology Neoplasia

OSTI ID:1000962

Spencer, Virginia A; Xu, Ren; Bissell, Mina

Decades ago, we and others proposed that the dynamic interplay between a cell and its surrounding environment dictates cell phenotype and tissue structure. Whereas much has been discovered about the effects of extracellular matrix molecules on cell growth and tissue specific gene expression, the nuclear mechanisms through which these molecules promote these physiological events remain unknown. Using mammary epithelial cells as a model, the purpose of this review is to discuss how the extracellular matrix influences nuclear structure and function in a three-dimensional context to promote epithelial morphogenesis and function in the mammary gland.

• Research Organization: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
• Sponsoring Organization: Life Sciences Division
• DOE Contract Number: DE-AC02-05CH11231; DEAC02-05CH1123, R01CA064786, U54CA126552, U54CA112970, R01CA057621
• OSTI ID: 1000962
• Report Number(s): LBNL-4099E; TRN: US1100247
• Journal Information: Journal Mammary Gland Biology Neoplasia, Vol. 15, Issue 1; Related Information: Journal Publication Date: March 2010
• Country of Publication: United States
• Language: English

Related Subjects

59
GENES
MAMMARY GLANDS
MORPHOGENESIS
NUCLEAR STRUCTURE
PHENOTYPE