High performance nanobio photocatalyst for targeted brain cancer therapy.

Journal Article · Tue Sep 01 00:00:00 EDT 2009 · Nano Lett.

DOI:https://doi.org/10.1021/nl901610f· OSTI ID:992395

Rozhkova, E; Ulasov, I; Dimitrijevic, N M; Lesniak, M; Rajh, T; Lai, B

We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO{sub 2} particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States)
• Sponsoring Organization: USDOE Office of Science (SC)
• DOE Contract Number: DE-AC02-06CH11357
• OSTI ID: 992395
• Report Number(s): ANL/CNM/JA-64375; TRN: US1007733
• Journal Information: Nano Lett., Vol. 9, Issue 9 ; Sep. 2009
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

43 PARTICLE ACCELERATORS
ABSORPTION
BRAIN
DEATH
DISTRIBUTION
FLUORESCENCE
MICROSCOPY
NEOPLASMS
OXYGEN
PERFORMANCE
SYNCHROTRONS
THERAPY