Tumors in Rubinstein-Taybi syndrome

Journal Article · Mon Mar 13 00:00:00 EST 1995 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320560125· OSTI ID:99082

Miller, R W ^[1]; Rubinstein, J H ^[2]

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1. National Cancer Institute, Bethesda, MD (United States)
2. Univ. of Cincinnati College of Medicine, OH (United States)

The 14 tumors reported in Rubinstein-Taybi syndrome since 1989, when added to the 22 previously reported, are beginning to show a pattern of neural and developmental tumors, especially of the head, which is malformed in the syndrome. Among the neoplasms were 12 of the nervous system: 2 each of oligodendroglioma, medulloblastoma, neuroblastoma, and 3 other benign tumors; 2 of nasopharyngeal rhabdomyosarcoma; and 1 each of leiomyosarcoma, seminoma, and embryonal carcinoma. Among the other benign tumors were an ondontoma, a choristoma, a dermoid cyst, and 2 pilomatrixomas. 20 refs., 1 tab.

• Sponsoring Organization: USDOE
• OSTI ID: 99082
• Journal Information: American Journal of Medical Genetics, Vol. 56, Issue 1; Other Information: PBD: 13 Mar 1995
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN CHROMOSOME 16
CHROMOSOMAL ABERRATIONS
GENETIC MAPPING
PATIENTS
CONGENITAL MALFORMATIONS
PHENOTYPE
NERVOUS SYSTEM DISEASES
BRAIN
NEOPLASMS
GENES