Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects.

Kodavanti, Prasada; Coburn, Cary; Moser, Virginia; MacPhail, Robert; Fenton, Suzanne; Stoker, Tammy; Birnbaum, Linda

doi:10.1093/toxsci/kfq105

Title: Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects.

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Abstract

Developmental effects of polybrominated diphenyl ethers (PBDEs) have been suspected due to their structural similarities to polychlorinated biphenyls (PCBs). This study evaluated neurobehavioral, hormonal, and reproductive effects in rat offspring perinatally exposed to a widely used pentabrominated commercial mixture, DE-71. Pregnant Long-Evans rats were exposed to 0, 1.7, 10.2, or 30.6 mg/kg/day DE-71 in corn oil by oral gavage from gestational day 6 to weaning. DE-71 did not alter maternal or male offspring body weights. However, female offspring were smaller compared with controls from postnatal days (PNDs) 35-60. Although several neurobehavioral endpoints were assessed, the only statistically significant behavioral finding was a dose-by-age interaction in the number of rears in an open-field test. Developmental exposure to DE-71 caused severe hypothyroxinemia in the dams and early postnatal offspring. DE-71 also affected anogenital distance and preputial separation in male pups. Body weight gain over time, reproductive tissue weights, and serum testosterone concentrations at PND 60 were not altered. Mammary gland development of female offspring was significantly affected at PND 21. Congener-specific analysis of PBDEs indicated accumulation in all tissues examined. Highest PBDE concentrations were found in fat including milk, whereas blood had the lowest concentrations on a wet weight basis. PBDE concentrationsmore »« less

Authors:

Kodavanti, Prasada ^[1]; Coburn, Cary ^[1]; Moser, Virginia ^[1]; MacPhail, Robert ^[1]; Fenton, Suzanne ^[2]; Stoker, Tammy ^[1]; Birnbaum, Linda ^[2]

U.S. Environmental Protection Agency, Durham, North Carolina
National Institute of Environmental Health Sciences (NIEHS)

Publication Date:: Tue Jun 01 00:00:00 EDT 2010

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: Work for Others (WFO)

OSTI Identifier:: 984395

DOE Contract Number:: DE-AC05-00OR22725

Resource Type:: Journal Article

Journal Name:: Toxicological Sciences

Additional Journal Information:: Journal Volume: 116; Journal Issue: 1; Journal ID: ISSN 1096-6080

Country of Publication:: United States

Language:: English

Subject:: 13 HYDRO ENERGY; BLOOD; BLOOD-BRAIN BARRIER; BRAIN; CORN OIL; DAMS; ETHERS; FATS; FEMALES; MALES; MAMMARY GLANDS; MILK; POLYCHLORINATED BIPHENYLS; PROGENY; TESTOSTERONE; THYROID HORMONES

Citation Formats


                    Kodavanti, Prasada, Coburn, Cary, Moser, Virginia, MacPhail, Robert, Fenton, Suzanne, Stoker, Tammy, and Birnbaum, Linda. Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects..  United States: N. p., 2010. 
        Web.  doi:10.1093/toxsci/kfq105.

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                    Kodavanti, Prasada, Coburn, Cary, Moser, Virginia, MacPhail, Robert, Fenton, Suzanne, Stoker, Tammy, & Birnbaum, Linda. Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects..  United States.  https://doi.org/10.1093/toxsci/kfq105

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                    Kodavanti, Prasada, Coburn, Cary, Moser, Virginia, MacPhail, Robert, Fenton, Suzanne, Stoker, Tammy, and Birnbaum, Linda. 2010.  
        "Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects.".  United States.  https://doi.org/10.1093/toxsci/kfq105.

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@article{osti_984395,

  title        = {Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects.},

  author       = {Kodavanti, Prasada and Coburn, Cary and Moser, Virginia and MacPhail, Robert and Fenton, Suzanne and Stoker, Tammy and Birnbaum, Linda},

  abstractNote = {Developmental effects of polybrominated diphenyl ethers (PBDEs) have been suspected due to their structural similarities to polychlorinated biphenyls (PCBs). This study evaluated neurobehavioral, hormonal, and reproductive effects in rat offspring perinatally exposed to a widely used pentabrominated commercial mixture, DE-71. Pregnant Long-Evans rats were exposed to 0, 1.7, 10.2, or 30.6 mg/kg/day DE-71 in corn oil by oral gavage from gestational day 6 to weaning. DE-71 did not alter maternal or male offspring body weights. However, female offspring were smaller compared with controls from postnatal days (PNDs) 35-60. Although several neurobehavioral endpoints were assessed, the only statistically significant behavioral finding was a dose-by-age interaction in the number of rears in an open-field test. Developmental exposure to DE-71 caused severe hypothyroxinemia in the dams and early postnatal offspring. DE-71 also affected anogenital distance and preputial separation in male pups. Body weight gain over time, reproductive tissue weights, and serum testosterone concentrations at PND 60 were not altered. Mammary gland development of female offspring was significantly affected at PND 21. Congener-specific analysis of PBDEs indicated accumulation in all tissues examined. Highest PBDE concentrations were found in fat including milk, whereas blood had the lowest concentrations on a wet weight basis. PBDE concentrations were comparable among various brain regions. Thus, perinatal exposure to DE-71 leads to accumulation of PBDE congeners in various tissues crossing blood-placenta and blood-brain barriers, causing subtle changes in some parameters of neurobehavior and dramatic changes in circulating thyroid hormone levels, as well as changes in both male and female reproductive endpoints. Some of these effects are similar to those seen with PCBs, and the persistence of these changes requires further investigation.},

  doi          = {10.1093/toxsci/kfq105},

  url          = {https://www.osti.gov/biblio/984395},
  journal      = {Toxicological Sciences},

  issn         = {1096-6080},

  number       = 1,

  volume       = 116,

  place        = {United States},

  year         = {Tue Jun 01 00:00:00 EDT 2010},

  month        = {Tue Jun 01 00:00:00 EDT 2010}

}

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