Arrays of probes for positional sequencing by hybridization

Cantor, Charles R; Prezetakiewiczr, Marek; Smith, Cassandra L; Sano, Takeshi

Title: Arrays of probes for positional sequencing by hybridization

Patent · Tue Jan 15 00:00:00 EST 2008

OSTI ID:983886

Cantor, Charles R ^[1]; Prezetakiewiczr, Marek ^[2]; Smith, Cassandra L ^[1]; Sano, Takeshi ^[3]

Boston, MA
East Boston, MA
Waltham, MA

This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods whereby sequence information is obtained rapidly and efficiently in discrete packages. That information can be used for the detection, identification, purification and complete or partial sequencing of a particular target nucleic acid. When coupled with a ligation step, these methods can be performed under a single set of hybridization conditions. The invention also relates to the replication of probe arrays and methods for making and replicating arrays of probes which are useful for the large scale manufacture of diagnostic aids used to screen biological samples for specific target sequences. Arrays created using PCR technology may comprise probes with 5'- and/or 3'-overhangs.

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Research Organization:: Boston University (Boston, MA)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-93ER61609

Assignee:: The Trustees of Boston University (Boston, MA)

Patent Number(s):: 7,319,003

Application Number:: 09/030,571

OSTI ID:: 983886

Country of Publication:: United States

Language:: English

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