Insights into the Interferon Regulatory Factor Activation from the Crystal Structure of Dimeric IRF5
Journal Article
·
· Nature Structural and Molecular Biology
The interferon regulatory factors (IRFs) are involved in the innate immune response and are activated by phosphorylation. The structure of a pseudophosphorylated IRF5 activation domain now reveals structural changes in the activated form that would turn an autoinhibitory region into a dimerization interface. In vivo analysis supports the relevance of such a dimer to transcriptional activation.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
- Sponsoring Organization:
- Doe - Office Of Science
- DOE Contract Number:
- DE-AC02-98CH10886
- OSTI ID:
- 980275
- Report Number(s):
- BNL-93193-2010-JA; TRN: US201015%%1660
- Journal Information:
- Nature Structural and Molecular Biology, Vol. 15, Issue 11
- Country of Publication:
- United States
- Language:
- English
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