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Title: Stress distribution and dimensional changes in chromatographic columns

Abstract

High pressures, in the kilobar range, are now used in liquid chromatography. Basic equations from mechanics are applied to investigate the stress state in several idealized chromatography tubes, and these stresses are evaluated with respect to the maximum allowable stresses predicted by several methods used in pressure vessel design. An analytical solution is developed for the dimensional changes of idealized tubes subjected to internal pressure, and the analytical solutions used to verify the results from a numerical approximation. Numerical approximations are then used to explore the effects of the end restraint provided by the end frits. Conclusions are derived regarding the requirements for a safe operation of these high pressure chromatography tubes.

Authors:
 [1];  [1];  [2]
  1. University of Tennessee, Knoxville (UTK)
  2. ORNL
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
978132
DOE Contract Number:  
DE-AC05-00OR22725
Resource Type:
Journal Article
Journal Name:
Journal of Chromatography A
Additional Journal Information:
Journal Volume: 1083; Journal Issue: 0
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION; LIQUID COLUMN CHROMATOGRAPHY; EXTRACTION COLUMNS; STRESS ANALYSIS; PRESSURE DEPENDENCE; ANALYTICAL SOLUTION; APPROXIMATIONS; SAFETY ENGINEERING; TUBES

Citation Formats

Chen, Feng, Drumm, Eric, and Guiochon, Georges A. Stress distribution and dimensional changes in chromatographic columns. United States: N. p., 2005. Web. doi:10.1016/j.chroma.2005.06.004.
Chen, Feng, Drumm, Eric, & Guiochon, Georges A. Stress distribution and dimensional changes in chromatographic columns. United States. https://doi.org/10.1016/j.chroma.2005.06.004
Chen, Feng, Drumm, Eric, and Guiochon, Georges A. 2005. "Stress distribution and dimensional changes in chromatographic columns". United States. https://doi.org/10.1016/j.chroma.2005.06.004.
@article{osti_978132,
title = {Stress distribution and dimensional changes in chromatographic columns},
author = {Chen, Feng and Drumm, Eric and Guiochon, Georges A},
abstractNote = {High pressures, in the kilobar range, are now used in liquid chromatography. Basic equations from mechanics are applied to investigate the stress state in several idealized chromatography tubes, and these stresses are evaluated with respect to the maximum allowable stresses predicted by several methods used in pressure vessel design. An analytical solution is developed for the dimensional changes of idealized tubes subjected to internal pressure, and the analytical solutions used to verify the results from a numerical approximation. Numerical approximations are then used to explore the effects of the end restraint provided by the end frits. Conclusions are derived regarding the requirements for a safe operation of these high pressure chromatography tubes.},
doi = {10.1016/j.chroma.2005.06.004},
url = {https://www.osti.gov/biblio/978132}, journal = {Journal of Chromatography A},
number = 0,
volume = 1083,
place = {United States},
year = {Fri Jul 01 00:00:00 EDT 2005},
month = {Fri Jul 01 00:00:00 EDT 2005}
}