Protein Modifications as Potential Biomarkers in Breast Cancer
Journal Article
·
· Biomarker Insights, 2009(4):191-200
OSTI ID:972544
A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry techniques have shown promise for identifying changes in PTMs. In this review, we summarize the current literature on PTMs identified in the plasma and tumor tissue of breast-cancer patients or in breast cell lines. We also discuss some of the analytical techniques currently being used to evaluate PTMs.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 972544
- Report Number(s):
- PNNL-SA-69899; 400412000; TRN: US201006%%127
- Journal Information:
- Biomarker Insights, 2009(4):191-200, Vol. 4
- Country of Publication:
- United States
- Language:
- English
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