An Anisotropic Fluid-Solid Model of the Mouse Heart

Conference · Fri Jan 01 00:00:00 EST 2010

OSTI ID:971883

Carson, James P; Kuprat, Andrew P; Jiao, Xiangmin; del Pin, Facundo; Einstein, Daniel R

A critical challenge in biomechanical simulations is the spatial discretization of complex fluid-solid geometries created from imaging. This is especially important when dealing with Lagrangian interfaces, as there must be at a minimum both geometric and topological compatibility between fluid and solid phases, with exact matching of the interfacial nodes being highly desirable. We have developed a solution to this problem and applied the approach to the creation of a 3D fluidsolid mesh of the mouse heart. First, a 50 micron isotropic MRI dataset of a perfusion-fixed mouse heart was segmented into blood, tissue, and background using a customized multimaterial connected fuzzy thresholding algorithm. Then, a multimaterial marching cubes algorithm was applied to produce two compatible isosurfaces, one for the blood-tissue boundary and one for the tissue-background boundary. A multimaterial smoothing algorithm that rigorously conserves volume for each phase simultaneously smoothed the isosurfaces. Next we applied novel automated meshing algorithms to generate anisotropic hybrid meshes with the number of layers and the desired element anisotropy for each material as the only input parameters. As the meshes are scale-invariant within a material and include boundary layer prisms, fluid-structure interaction computations would have a relative error equilibrated over the entire mesh. The resulting model is highly detailed mesh representation of the mouse heart, including features such as chordae and coronary vasculature, that is also maximally efficient to produce the best simulation results for the computational resources available

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 971883
• Report Number(s): PNNL-SA-68145; TRN: US201004%%335
• Resource Relation: Conference: Computers in Cardiology 2009, Park City, Utah September 13-16, 2009, 36:377-380
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
ALGORITHMS
ANISOTROPY
BLOOD
BOUNDARY LAYERS
COMPATIBILITY
COMPUTERS
FLUID-STRUCTURE INTERACTIONS
LAGRANGIAN FUNCTION
PRISMS
SIMULATION
mesh
geometry
lagrangian multiscale
ventricle
atrial
coronary
flow