Synthesis of hybrid gold/iron oxide nanoparticles in block copolymer micelles for imaging, drug delivery and magnetic hyperthermia.

Journal Article · Thu Oct 01 00:00:00 EDT 2009 · IEEE Trans. Magn.

DOI:https://doi.org/10.1109/TMAG.2009.2024000· OSTI ID:965248

Kim, D -H; Rozhkova, E A; Rajh, T; Bader, S D; Novosad, V

In our study, hybrid gold/iron oxide loaded thermoresponsive micelles were synthesized for combined hyperthermia and chemotherapy, and optical imaging. Polymeric micelles made of amphiphilic block copolymer of poly(N-isopropylacrylamide-co-acrylamide)-block-poly({var_epsilon}-caprolactone) were conjugated with gold/iron oxide particles which are self-assembled at the hydrophobic polymer core. Thermal sensitivity and magnetic and optical properties of the hybrid gold/iron oxide micelles were investigated for the combined therapy and optical imaging.

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States)
• Sponsoring Organization: USDOE Office of Science (SC)
• DOE Contract Number: DE-AC02-06CH11357
• OSTI ID: 965248
• Report Number(s): ANL/MSD/JA-64481; IEMGAQ; TRN: US0903591
• Journal Information: IEEE Trans. Magn., Vol. 45, Issue 10 ; Oct. 2009; ISSN 0018-9464
• Country of Publication: United States
• Language: ENGLISH

Related Subjects

60 APPLIED LIFE SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
CHEMOTHERAPY
COMBINED THERAPY
COPOLYMERS
HYPERTHERMIA
OPTICAL PROPERTIES
OXIDES
POLYMERS
SENSITIVITY
SYNTHESIS