Preparation and characterization of a tritiated derivative of CP-96.345-a nonpeptide antagonist of the substance P receptor-with a high specific radioactivity

Journal Article · Tue Sep 20 00:00:00 EDT 1994 · Russian Journal of Bioorganic Chemistry

OSTI ID:96069

Kasheverox, I E; Utkin, Y N; Tsetlin, V I ^[1]; Zaitsev, D A ^[2]

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1. Institute of Biorganic Chemistry, Moscow (Russian Federation)
2. Institute of Molecular Genetics, Moscow (Russian Federation)

A tritiated derivative of CP-96.345 with a specific activity of 84 Ci/mmole has been obtained. The radioactive compound has been characterized in comparison with the unlabeled analogue for its capacity for inhibiting the binding of the [{sup 125}I]iodinated derivative of substance P with brain membrane preparations from various sources. The capacity of [{sup 3}H]CP-96.345 for directly and specifically binding with membranes from the same sources has also been investigated by the method of radioligand analysis.

• OSTI ID: 96069
• Journal Information: Russian Journal of Bioorganic Chemistry, Vol. 20, Issue 11; Other Information: PBD: 20 Sep 1994; TN: Translated from Bioorganicheskaya Khimiya; 20: No. 11, 1162-1168(Nov 1994)
• Country of Publication: United States
• Language: English

Related Subjects

40 CHEMISTRY
55 BIOLOGY AND MEDICINE
BASIC STUDIES
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
TRITIUM COMPOUNDS
INFLAMMATION
NEUROREGULATORS
BLOOD PRESSURE