Reversible PH Lability of Cross-Linked Vault Nanocapsules
Abstract
Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10 000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible cross-linking of recombinant vaults such that they may be closed and opened in a controllable manner.
- Authors:
- Publication Date:
- Research Org.:
- SLAC National Accelerator Lab., Menlo Park, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 953519
- Report Number(s):
- SLAC-REPRINT-2009-364
TRN: US201002%%1347
- DOE Contract Number:
- AC02-76SF00515
- Resource Type:
- Journal Article
- Journal Name:
- Nano Lett. 8:3510,2008
- Additional Journal Information:
- Journal Volume: 8; Journal Issue: 10
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; CROSS-LINKING; DELIVERY; DIMENSIONS; DRUGS; HUMAN POPULATIONS; POTENTIALS; PROTEINS; RANGE; REAGENTS; VEHICLES; Other,OTHER
Citation Formats
Yu, M, Ng, B C, Rome, L H, Tolbert, S H, and Monbouquette, H G. Reversible PH Lability of Cross-Linked Vault Nanocapsules. United States: N. p., 2009.
Web.
Yu, M, Ng, B C, Rome, L H, Tolbert, S H, & Monbouquette, H G. Reversible PH Lability of Cross-Linked Vault Nanocapsules. United States.
Yu, M, Ng, B C, Rome, L H, Tolbert, S H, and Monbouquette, H G. 2009.
"Reversible PH Lability of Cross-Linked Vault Nanocapsules". United States.
@article{osti_953519,
title = {Reversible PH Lability of Cross-Linked Vault Nanocapsules},
author = {Yu, M and Ng, B C and Rome, L H and Tolbert, S H and Monbouquette, H G},
abstractNote = {Vaults are ubiquitous, self-assembled protein nanocapsules with dimension in the sub-100 nm range that are conserved across diverse phyla from worms to humans. Their normal presence in humans at a copy number of over 10 000/cell makes them attractive as potential drug delivery vehicles. Toward this goal, bifunctional amine-reactive reagents are shown to be useful for the reversible cross-linking of recombinant vaults such that they may be closed and opened in a controllable manner.},
doi = {},
url = {https://www.osti.gov/biblio/953519},
journal = {Nano Lett. 8:3510,2008},
number = 10,
volume = 8,
place = {United States},
year = {Thu May 28 00:00:00 EDT 2009},
month = {Thu May 28 00:00:00 EDT 2009}
}
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