Structural Studies of Copper(I) Complexes of Amyloid-Beta Peptide Fragments: Formation of Two-Coordinate Bis(Histidine) Complexes
Journal Article
·
· Angew. Chem. Int. Ed. 47:9084,2008
OSTI ID:953121
The beta bind: Copper(I) binds to amyloid {beta}-peptide fragments (see structure) as a stable bis(histidine), two-coordinate, near-linear complex, even in the presence of potential additional ligands. As has been proposed or assumed in other studies, the copper(I)-peptide complexes react with dioxygen to form the reactive oxygen species H{sub 2}O{sub 2}, without the need for a third histidine ligand to promote the chemistry.
- Research Organization:
- SLAC National Accelerator Lab., Menlo Park, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-76SF00515
- OSTI ID:
- 953121
- Report Number(s):
- SLAC-REPRINT-2009-163; ACIEAY; TRN: US200914%%201
- Journal Information:
- Angew. Chem. Int. Ed. 47:9084,2008, Vol. 47, Issue 47; ISSN 0570-0833
- Country of Publication:
- United States
- Language:
- English
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