Polymer Formulations for Cartilage Repair
Regeneration of destroyed articular cartilage can be induced by transplantation of cartilage cells into a defect. The best results are obtained with the use of autologus cells. However, obtaining large amounts of autologus cartilage cells causes a problem of creating a large cartilage defect in a donor site. Techniques are currently being developed to harvest a small number of cells and propagate them in vitro. It is a challenging task, however, due to the fact that ordinarily, in a cell culture on flat surfaces, chondrocytes do not maintain their in vivo phenotype and irreversibly diminish or cease the synthesis of aggregating proteoglycans. Therefore, the research is continuing to develop culture conditions for chondrocytes with the preserved phenotype.
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 951043
- Report Number(s):
- PNNL-SA-34785; KP1402010; TRN: US200911%%188
- Resource Relation:
- Conference: Transactions: 27th annual meeting, Society for Biomaterials, in conjunction with the 33rd International Biomaterials Symposium, 24:566
- Country of Publication:
- United States
- Language:
- English
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