Evaluation of risk assessment guideline levels for the chemical warfare agents mustard, GB, and VX.
The U.S. Army has estimated acute lethality guideline levels for inhalation of the chemical warfare agents mustard, GB, and VX. These levels are expressed as dosages measured in milligram-minutes per cubic meter (mg-min/m3). The National Advisory Council has also proposed acute emergency guideline levels (AEGLs) for the agents. The AEGLs are threshold exposure limits for the general public for mild effects, serious adverse effects, and lethality. They are expressed as air concentrations (in units of mg/m3) and are applicable to emergency exposure periods ranging from 10 min to 8 h. The report discusses strengths and deficiencies in the levels, important parameters (i.e., exposure time, breathing rate) that need to be explicitly addressed in deriving the guideline levels, and possible impacts that could result from using AEGLs instead of guideline dosages in future assessments.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOD
- DOE Contract Number:
- DE-AC02-06CH11357
- OSTI ID:
- 949398
- Report Number(s):
- ANL/EA/JA-40567; RTOPDW; TRN: US201012%%194
- Journal Information:
- Regul. Toxicol. Pharmacol., Vol. 35, Issue 3 ; Jun. 2002; ISSN 0273-2300
- Country of Publication:
- United States
- Language:
- ENGLISH
Similar Records
Toxicity of the organophosphate chemical warfare agents GA, GB, and VX: Implications for public protection
Evaluation of Chemical Warfare Agent Percutaneous Vapor Toxicity: Derivation of Toxicity Guidelines for Assessing Chemical Protective Ensembles.