Multiple Mechanisms are Responsible for Transactivation of the Epidermal Growth Factor Receptor in Mammary Epithelial Cells
Journal Article
·
· Journal of Biological Chemistry, 283(46):31477-31487
REVIEW ENTIRE DOCUMENT AT: https://pnlweb.pnl.gov/projects/bsd/ERICA%20Manuscripts%20for%20Review/KD%20Rodland%20D7E80/HMEC_transactivation_ms01_15+Figs.pdf ABSTRACT: Using a single nontransformed strain of human mammary epithelial cells, we found that the ability of multiple growth factors and cytokines to induce ERK phosphorylation was dependent on EGFR activity. These included lysophosphatidic acid (LPA), uridine triphosphate, growth hormone, vascular endothelial growth factor, insulin-like growth factor-1 (IGF-1), and tumor necrosis factoralpha. In contrast, hepatocyte growth factor could stimulate ERK phosphorylation independent of EGFR activity...
- Research Organization:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 947463
- Report Number(s):
- PNNL-SA-59460; JBCHA3; TRN: US200909%%94
- Journal Information:
- Journal of Biological Chemistry, 283(46):31477-31487, Vol. 283, Issue 46; ISSN 0021-9258
- Country of Publication:
- United States
- Language:
- English
Similar Records
Induced autocrine signaling through the epidermal growth factor receptor contributes to the response of mammary epithelial cells to tumor necrosis factor alpha
Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling
Bombesin receptor-activated protein regulates neutrophil elastase-induced mucin5AC hypersecretion in human bronchial epithelial cells
Journal Article
·
Fri Apr 30 00:00:00 EDT 2004
· Journal of Biological Chemistry
·
OSTI ID:947463
+4 more
Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling
Journal Article
·
Fri Aug 15 00:00:00 EDT 2014
· Toxicology and Applied Pharmacology
·
OSTI ID:947463
+2 more
Bombesin receptor-activated protein regulates neutrophil elastase-induced mucin5AC hypersecretion in human bronchial epithelial cells
Journal Article
·
Tue Aug 15 00:00:00 EDT 2017
· Experimental Cell Research
·
OSTI ID:947463
+3 more