Toward Electronic Conductance Characterization of DNA Nucleotide Bases

Conference · Thu Mar 01 00:00:00 EST 2007

OSTI ID:944952

Krstic, Predrag S ^[1]; Wells, Jack C ^[1]; Fuentes-Cabrera, Miguel A ^[1]; Xu, Dong ^[2]; Lee, James Weifu ^[1]

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1. ORNL
2. University of Missouri, Columbia

We calculate electron-transport properties within equilibrium, linear transport theory through the DNA nucleotide bases spanning two gold nanowires. Our quantum mechanical calculations show that single configurations of DNA bases A, C, T, and G have significantly different charge conductance characteristics. This result is consistent with the notion that it is possible to read the nucleotide base sequence on an individual DNA heteropolymer which is moving through a gap between electrically biased nanoelectrodes by measuring the changes in the electron-transport conductance.

• Research Organization: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
• Sponsoring Organization: USDOE Office of Science (SC)
• DOE Contract Number: DE-AC05-00OR22725
• OSTI ID: 944952
• Resource Relation: Conference: China International Conference on Nanoscience and Technology (ChinaNano 2005), Beijing, China, 20050609, 20050611
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DNA
GOLD
NUCLEOTIDES
TRANSPORT THEORY