The crystal structure of GROEL at 2.8 {angstrom}.
Journal Article
·
· Nature
OSTI ID:937733
The crystal structure of Escherichia coli GroEL shows a porous cylinder of 14 subunits made of two nearly 7-fold rotationally symmetrical rings stacked back-to-back with dyad symmetry. The subunits consist of three domains: a large equatorial domain that forms the foundation of the assembly at its waist and holds the rings together; a large loosely structured apical domain that forms the ends of the cylinder; and a small slender intermediate domain that connects the two, creating side windows. The three-dimensional structure places most of the mutationally defined functional sites on the channel walls and its outward invaginations, and at the ends of the cylinder.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- ER
- DOE Contract Number:
- DE-AC02-06CH11357
- OSTI ID:
- 937733
- Report Number(s):
- ANL/CMB/JA-15614; NATUAS; TRN: US200905%%508
- Journal Information:
- Nature, Vol. 371, Issue 1995; ISSN 0028-0836
- Country of Publication:
- United States
- Language:
- ENGLISH
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