MASIC: a software program for fast quantitation and flexible visualization of chromatographic profiles from detected LC-MS(/MS) features

Journal Article · Sun Jun 01 00:00:00 EDT 2008 · Computational Biology and Chemistry, 32(3):215-217

DOI:https://doi.org/10.1016/j.compbiolchem.2008.02.006· OSTI ID:936757

Monroe, Matthew E.; Shaw, Jason L.; Daly, Don S.; Adkins, Joshua N.; Smith, Richard D.

Quantitative analysis of liquid chromatography (LC)- mass spectrometry (MS) and tandem mass spectrometry (MS/MS) data is essential to many proteomics studies. We have developed MASIC to accurately measure peptide abundances and LC elution times in low-resolution LC-MS/MS analyses. This software program uses an efficient processing algorithm to quickly generate mass specific selected ion chromatograms from a dataset and provides an interactive browser that allows users to examine individual chromatograms in a variety of fashions. The improved elution time estimates afforded by MASIC increase the utility of LC-MS/MS data in the accurate mass and time (AMT) tag approach to proteomics.

• Research Organization: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 936757
• Report Number(s): PNNL-SA-52621; 400412000
• Journal Information: Computational Biology and Chemistry, 32(3):215-217, Vol. 32, Issue 3
• Country of Publication: United States
• Language: English