Crystal Structure of a Complete Ternary Complex of TCR, Superantigen and Peptide-MHC
Journal Article
·
· Nature Structural and Molecular Biology
'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-{angstrom} resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR V{beta} but with TCR V{alpha}.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
- Sponsoring Organization:
- Doe - Office Of Science
- DOE Contract Number:
- DE-AC02-98CH10886
- OSTI ID:
- 930634
- Report Number(s):
- BNL-81007-2008-JA; TRN: US200901%%154
- Journal Information:
- Nature Structural and Molecular Biology, Vol. 14, Issue 2
- Country of Publication:
- United States
- Language:
- English
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